Registration Dossier
Registration Dossier
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EC number: 239-263-3 | CAS number: 15206-55-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Unsuitable test system
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute toxicity study with mice. Application: intraperitoneal; Observation: 14 days
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Methyl benzoylformate
- EC Number:
- 239-263-3
- EC Name:
- Methyl benzoylformate
- Cas Number:
- 15206-55-0
- Molecular formula:
- C9H8O3
- IUPAC Name:
- methyl oxo(phenyl)acetate
- Details on test material:
- - Physical state: liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean: male: 23,3g; female: 22,7g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 0,5% aqueous solution with 2-3 drops of cremophor
- Doses:
- 3160, 2150, 1470, 1000, 681, 46,4 mg/kg bw
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 100 - 3 100 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals died at the highest dose within 24 hours. At 2150 mg/kg 2 males and 1 females died in the first hour after application. At 1470 mg/kg 1 male and 1 female died 24 hours after application.
- Clinical signs:
- Animals showed staggering, atonia, narcotic like symptoms, spastical gait, exsiccosis, and loss of pain and corneal reflex.
- Body weight:
- Normal body weight gain.
- Gross pathology:
- intra-abdominal adhesion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
