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Diss Factsheets
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EC number: 403-960-2 | CAS number: 126877-05-2 C.I. DISPERSE RED 367
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 472 (Genetic Toxicology: Escherichia coli, Reverse Mutation Assay)
- GLP compliance:
- yes
- Type of assay:
- bacterial gene mutation assay
Test material
- Reference substance name:
- 2-ethoxyethyl-2-(4-(2,6-dihydro-2,6-dioxo-7-phenyl-1,5-dioxaindacen-3-yl)phenoxy)acetate
- EC Number:
- 403-960-2
- EC Name:
- 2-ethoxyethyl-2-(4-(2,6-dihydro-2,6-dioxo-7-phenyl-1,5-dioxaindacen-3-yl)phenoxy)acetate
- Cas Number:
- 126877-05-2
- Molecular formula:
- C28H22O8
- IUPAC Name:
- 2-ethoxyethyl 2-(4-{5,11-dioxo-12-phenyl-4,10-dioxatricyclo[7.3.0.0³,⁷]dodeca-1(12),2,6,8-tetraen-6-yl}phenoxy)acetate
- Details on test material:
- - Sample reference: Ref NBW 8809/52
- Supplier: ICI Colours and Fine Chemicals, Blackley, UK.
- CTl reference number: Y04203/002/001.
- Physical state: red powder
- Analytical purity: 90%
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- E. coli WP2 uvr A pKM 101
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9
- Test concentrations with justification for top dose:
- 5556 µg/plate,
5000 µg/plate,
1000 µg/plate,
200 µg/plate
40 µg/plate
8 µg/plate
1.6 µg/plate (not WP2)
=>3 plates per dose and for each strain
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Remarks:
- Dimethylsulphoxide (DMSO)
- Positive controls:
- yes
Results and discussion
Any other information on results incl. tables
The Substance has been evaluated in the bacterial mutagenicity assay of Maron and Ames (1983), using five strains of Salmonella typhimurium (TAI535, TA1537, TA1538, TA98 and-TA100), and also one strain of Escherichia coli (WP2 uvrA pKM101), following protocols complying with OECD Guidelines Nos. 471 and 472 (OECD, 1983a and 1983b).
In two separate experiments, the compound did not induce any significant, reproducible increases in the observed numbers of revertant colonies in strains TA1535 and WP2 uvrA pKM101 in either the presence or absence of S9.
In the first experiment in strain TAl537 a limited, dose-related increase in the observed number of revertant colonies was obtained. This had only lmited reproducibility in the second experiment.
In strains TA1538, TA98 and TA100 (both with and without S9) significant, dose-related increases in the observed numbers of revertant colonies were obtained in each experiment.
In each experiment, the positive controls responded as expected, indicating that the assay was working satisfactorily.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this assay, the Substance therefore gave an unequivocal positive, ie mutagenic, response in strains TA1538, TA98 and TA100 in both the presence and absence of an auxiliary metabolising system (S9).
- Executive summary:
Under the conditions of this assay, the Substance therefore gave an unequivocal positive, ie mutagenic, response in strains TA1538, TA98 and TA100 in both the presence and absence of an auxiliary metabolising system (S9).
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