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Partition coefficient

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Description of key information

According to column 2 of REACH Annex VII, performing of an experimental study is not useful in case of hydrolytical instability. In this case a calculated value is required: log Pow = 7.74,  obtained using EPIWIN 4.00 with an idealised structure (one isocyanate group of 4,4-MDI is modified with 2-ethyl-hexanol). An experimental value of 4,4-MDI of 4.51 is available. This component is also present in the substance.

Key value for chemical safety assessment

Log Kow (Log Pow):
7.74
at the temperature of:
20 °C

Additional information

Given the reactivity of MDI MT and 4,4 -MDI in the aquatic environment and its transient existence in water, the log Pow has little direct relevance to the calculation of its environmental fate and ecotoxicity.