Propan-2-ol

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable for assessement

Data source

Reference

Reference Type:

publication

Title:

Range finding toxicity data - List V

Author:

Smyth H.F., Carpenter C.P., Weil C.S., Pozzani U.C

Year:

1954

Bibliographic source:

Arch. ind. hyg. occupat. med. 10, 61-68.

Materials and methods

Principles of method if other than guideline:

Method: Draize Test
Eye injury in rabbits records the degree of corneal necrosis from various volumes and concentrations of chemical, as detailed by Carpenter and Smyth Am. J. Ophth. 29 :1363, 1946

GLP compliance:

no

Remarks:

pre-dates GLP

Test material

Test material information

Constituent 1

Reference substance name:

Automatically generated during migration to IUCLID 6, no data available

IUPAC Name:

Automatically generated during migration to IUCLID 6, no data available

Details on test material:

propan-1-ol
Analytical purity: No data

Test animals / tissue source

Species:

rabbit

Strain:

other: Albino

Test system

Vehicle:

unchanged (no vehicle)

Details on study design:

Before instillation, the rabbit eyes were treated with 5% aqueous solution of fluorescein sodium. 20 sec later, the eyes were flushed with distilled water. After a 2 h interval to allow the eye to return to normal, 0.005 ml of the undiluted test substance is applied to the center of the cornea while the lids are retracted. About one minute later, the lids are released. This procedure is necessary to prevent the removal of a portion dose by the very efficient wiping system of the lids before intimate contact has been made with the eye. Eighteen to 24 h later, the eye is examined in strong diffuse daylight, then stained with fluorescein, and the injury scored. Guided by the result and a table of injury grades, additional applications are made until the chemical is assigned. If large volumes are applied, the lids are held closed for one minute before the animal is released.


Grade 1 in the table indicates at most a very small area of necrosis resulting from 0.5 ml of undiluted chemical in the eye ; Grade 5 indicates a so-called severe burn from 0.005 ml and grade 10 indicates a severe burn from 0.5 ml of a 1% solution in water or propylene glycol.

Results and discussion

Any other information on results incl. tables

The test substance caused a grade 5 injury to the rabbit eye

Applicant's summary and conclusion

Interpretation of results:

highly irritating

Remarks:

Migrated information Criteria used for interpretation of results: not specified

Conclusions:

Highly irritating