Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Available data in the IUCLID Chemical Data Sheet; the data have not undergone any evaluation by the European Commission. It's not known if the study was performed under GLP. Details on the test method are not known.

Data source

Reference
Reference Type:
grey literature
Title:
Iuclid Data set Substance ID 98-56-6
Author:
European Chemicals Bureau
Year:
2000
Bibliographic source:
ESIS
Report date:
2000

Materials and methods

Principles of method if other than guideline:
Guideline not available
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chloro-α,α,α-trifluorotoluene
EC Number:
202-681-1
EC Name:
4-chloro-α,α,α-trifluorotoluene
Cas Number:
98-56-6
Molecular formula:
C7H4ClF3
IUPAC Name:
1-chloro-4-(trifluoromethyl)benzene

Method

Test concentrations with justification for top dose:
0.01, 0.1, 1, 5, 10 ul/plate

Results and discussion

Test results
Species / strain:
not specified
Metabolic activation:
with
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative