Registration Dossier
Registration Dossier
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EC number: 403-360-0 | CAS number: 42405-40-3 BONTRON E-84; E-84
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline and GLP compliant study
Data source
Reference
- Reference Type:
- other: : Inquiry result from ECHA
- Title:
- Unnamed
- Year:
- 2 011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 84/449/EEC, Method B12 Micronucleus OECD Guideline No. 474
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Bis(3,5-bis(1,1-dimethylethyl)-2-hydroxybenzoato-O1,O2)zinc
- EC Number:
- 403-360-0
- EC Name:
- Bis(3,5-bis(1,1-dimethylethyl)-2-hydroxybenzoato-O1,O2)zinc
- Cas Number:
- 42405-40-3
- Molecular formula:
- C30H42O6Zn
- IUPAC Name:
- bis(3,5-bis(1,1-dimethylethyl)-2-hydroxybenzoato-O1,O2)zinc
Constituent 1
Test animals
- Species:
- other: Mouse, Charles River CD-1
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- Corn oil
- No. of animals per sex per dose:
- Male: 1000 mg/kg; No of animals: 5; Sacrifice time: 24 hours
Male: 1000 mg/kg; No of animals: 5; Sacrifice time: 48 hours
Male: 1000 mg/kg; No of animals: 5; Sacrifice time: 72 hours
Female: 1000 mg/kg; No of animals: 5; Sacrifice time: 24 hours
Female: 1000 mg/kg; No of animals: 5; Sacrifice time: 48 hours
Female: 1000 mg/kg; No of animals: 5; Sacrifice time: 72 hours
Results and discussion
- Additional information on results:
- Doses producing toxicity:
Treatment with 1000 mg/kg was clearly toxic for the mice and 6 mice (2 males, 4 females) died within 2 hours of dosing.
There was no significant decrease in the ratio of poly-to normochromatic erythorcytes at any of the three sacrifice times after treatment with the test substance.
Observations:
During the first 2 hours, all animals treated with the test substance showed sluggishness. No other findings were noted.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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