Registration Dossier
Registration Dossier
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EC number: 233-797-0 | CAS number: 10361-82-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological and pharmacological effects of gadolinium and samarium chlorides
- Author:
- T. J. Haley, K. Raymond, N. Komesu, and H. C. Upham
- Year:
- 1 961
- Bibliographic source:
- Br J Pharmacol Chemother. 1961 December; 17(3): 526–532.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Samarium (III) chloride hexahydrate
- EC Number:
- 233-797-0
- EC Name:
- Samarium (III) chloride hexahydrate
- Cas Number:
- 10361-82-7
- Molecular formula:
- Cl3Sm
- IUPAC Name:
- samarium (III) chloride hexahydrate
- Details on test material:
- - purity 99%
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- Each rabbit had one eye exposed to 1 mg of crystals of samarium chloride, while the other eye served as a control.
- Duration of treatment / exposure:
- single treatment
- Observation period (in vivo):
- 24 hours
- Number of animals or in vitro replicates:
- 3
Results and discussion
Any other information on results incl. tables
The introduction of 1 mg of samarium chlorides into the conjunctival sac of the eyes of rabbits resulted in an immediate increase in the rate of blinking and a redness of the palpebral coujunctiva within 1 hr.
After 24 hr there was no evidence of corneal or iris damage, conjunctival irritation, chemosis or increased lacrimal discharge. Apparently the natural buffering capacity of the lacrimal Huid was suflicient to counteract the nascent hydrochloric acid released when the gadolinium or samarium chlorides dissolved in the tears.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information
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