Registration Dossier
Registration Dossier
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EC number: 207-975-3 | CAS number: 503-74-2
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
In a cell growth inhibition test using cultures of Tetrahymwena pyriformis, IC50 for isovaleric acid was determined to be 224 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 224 mg/L
Additional information
From two tests identified, only one test is valid (Schulz, 2006). The documentation of the other (Hoechst AG, 1979) is insufficient for assessment.
Schulz 1997
In a valid 40 hr growth inhibition study, test cultures of the cilliate Tetrahymena pyriformis were exposed to isovaleric acid at five graduate concentrations under static conditions (individual concentrations not reported). The assay was performed in three independent replicate runs on the basis of a preceding range finding test.
The IC50 value based on cell density was determined to be 224 mg/L indicating low to moderate toxicity of isovaleric acid to aqueous microorganisms (cilliates) (Schultz, 2006).
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