Registration Dossier
Registration Dossier
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EC number: 209-865-0 | CAS number: 595-37-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2-dimethylbutyric acid
- EC Number:
- 209-865-0
- EC Name:
- 2,2-dimethylbutyric acid
- Cas Number:
- 595-37-9
- Molecular formula:
- C6H12O2
- IUPAC Name:
- 2,2-dimethylbutanoic acid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 7 days
- Number of animals:
- 3 male, 3 female
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information
- Conclusions:
- A single 24 h application of the test material to occluded rabbit skin ws severely irritating.
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