Registration Dossier
Registration Dossier
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EC number: 210-155-8 | CAS number: 608-25-3
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 428 (Skin Absorption: In Vitro Method)
- Version / remarks:
- draft version
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-methylresorcinol
- EC Number:
- 210-155-8
- EC Name:
- 2-methylresorcinol
- Cas Number:
- 608-25-3
- Molecular formula:
- C7H8O2
- IUPAC Name:
- 2-methylbenzene-1,3-diol
Constituent 1
Test animals
- Species:
- pig
Results and discussion
Any other information on results incl. tables
In vitro absorption/percutaneous penetration out of a basic hair dyeing formulation with and without a developer (excised pig skin)
Guideline: OECD draft 428
Species: pig
Group: 0.38 mm dermatomed skin from 2 animals; total 8 chambers per each of 3 experiments
Test substance 2 -methylresorcinol; (radio-labelled [14C] 2 -methylresorcinol)
Batch: SAT030630; (radio-labelled SAT 030759)
Purity: / (radio-labelled: 99.65%)
Dose: 1.8% in formulations with coupler and/or hydrogen peroxide; 1.8% in water
Receptor fluid: Physiological buffered saline
In this in vitro dermal penetration study in pig skin the amount of substance systemically available from a standard cream formulation with or without hydrogen peroxide was found to be 0.85 ± 0.78 μg/cm² (0.45%) and 8.38 ± 5.41 μg/cm² (4.48%), respectively and 32.2 ± 11.91 μg/cm² (17.18%) for the aqueous solution.
The maximum value observed in the experiment was 2.07 μg/cm² with hydrogen peroxide and 12.09 μg/cm² without hydrogen peroxide.
Comment: skin penetration of the formulation with and without H2O2 differs greatly but is highest in water.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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