Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-677-9 | CAS number: 19190-61-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- methyl 2,2,3,3,4,4-hexafluoro-4-[(1,2,2-trifluoroethenyl)oxy]butanoate
- EC Number:
- 700-677-9
- Cas Number:
- 19190-61-5
- Molecular formula:
- C7H3F9O3
- IUPAC Name:
- methyl 2,2,3,3,4,4-hexafluoro-4-[(1,2,2-trifluoroethenyl)oxy]butanoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- maize oil
- Remarks:
- lowest dose group only
- Doses:
- 2000 mg/kg bw
300 mg/kg bw
50 mg/kg bw - No. of animals per sex per dose:
- 2000 and 300 mg/kg bw group: 3 females each
50 mg/kg bw groups: 2 x 3 females - Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 50 - < 300 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 2000 mg/kg bw group: 3/3
300 mg/kg bw group: 3/3
50 mg/kg bw group: 0/6 - Clinical signs:
- other: 2000 mg/kg bw group: Sluggishness (3/3), Blepharospasm (3/3), piloerection (3/3), coldness (3/3), coma 300 mg/kg bw group: Sluggishness (3/3), Blepharospasm (3/3), Ataxia (1/3), encrustation eye (1/3), piloerection (3/3), coldness (2/3), coma (2/3) 50 mg/
- Gross pathology:
- 2000 mg/kg bw group: No treatment related gross alterations.
300 mg/kg bw group: One animal showed pale kidneys and a dark liver. No treatment related gross alterations for the other animals of this group.
50 mg/kg bw groups: No treatment related gross alterations.
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 value is considered to be between 50 and 300 mg/kg bw. The test substance is considered to be toxic if swalloed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
