Registration Dossier
Registration Dossier
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EC number: 204-688-5 | CAS number: 124-19-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract only.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Paragraph 191.1(f)(1) of the Final Order, Enforcement Regulations, United States Federal Register. Vol. 26, No. 155, p. 7336, 1961-08-12
- GLP compliance:
- no
- Remarks:
- Study predates GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Nonanal
- EC Number:
- 204-688-5
- EC Name:
- Nonanal
- Cas Number:
- 124-19-6
- Molecular formula:
- C9H18O
- IUPAC Name:
- nonanal
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sherman-Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: 24 hours
- Diet: Available ad libitum
- Water: Available ad libitum
- Acclimation period: 1 week
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5 animals/sex
- Control animals:
- no
- Details on study design:
- Animals were observed for 14 days.
- Statistics:
- None
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortalities were observed.
- Clinical signs:
- other: Diuresis was noted soon after dosing followed by lethargy and dullness. Recovery was complete 24-48 hours after dosing.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material was assessed for acute oral toxicity using rats exposed to the test material by oral gavage. The acute oral LD50 for the test material was >5000 mg/kg bw.
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