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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
18. Jul 1979 - 26. Jul 1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Principles of method if other than guideline:
BASF-Test:
Two animals were treated for 3 min or 1 h using occlusive conditions. An application site of 2 x 2 cm was covered with the liquid test substance. The animals were observed for 8 days and skin changes were recorded daily.

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N-ethylpropylamine
EC Number:
243-573-4
EC Name:
N-ethylpropylamine
Cas Number:
20193-20-8
Molecular formula:
C5H13N
IUPAC Name:
N-ethylpropan-1-amine
Details on test material:
- Name of test material (as cited in study report): Aethylpropylamin
- Physical state: liquid
- Analytical purity: 99 %

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 3.4 kg (mean)

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
yes, concurrent no treatment
Duration of treatment / exposure:
3 min or 1 h
Observation period:
8 days
Number of animals:
2 for each exposure period
Details on study design:
TEST SITE
- Area of exposure: 2 x 2 cm


REMOVAL OF TEST SUBSTANCE
- Washing (if done): concentrated Lutrol and 50 % Lutrol
- Time after start of exposure: 3 min or 1 h

SCORING SYSTEM:
according to Draize

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: necrosis
Basis:
animal: 1 & 2
Time point:
other: 8 days
Remarks on result:
other: full thickness necrosis after 3 min and 1 h exposure at the end of the observation period of 8 days
Irritation parameter:
erythema score
Basis:
mean
Remarks:
(animal 1 - 2)
Time point:
24/48 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks:
(within 8 days)
Remarks on result:
other: 3 min and 1 h exposure; 72 h reading is missing.
Irritation parameter:
edema score
Basis:
mean
Remarks:
(animal 1 - 2)
Time point:
24/48 h
Score:
2
Max. score:
4
Reversibility:
not reversible
Remarks:
(within 8 days)
Remarks on result:
other: 3 min and 1 h exposure; 72 h reading is missing

Any other information on results incl. tables

72 h reading is missing

Exposure:  3 min Comment
Animal  Reading  Erythema Edema  
1 3 min 2 2 brownish
2 3 min 2 2 brownish
1 24 h 4 2 Necrosis
2 24 h 4 2 Necrosis
1 48 h 4 2 Necrosis
2 48 h 4 2 Necrosis
1 5 d 4 2 Necrosis
2 5 d 4 2 Necrosis
1 8 d 4 2 Necrosis; full thickness
2 8 d 4 2 Necrosis; full thickness
mean (animal 1 & 2) 24 - 48 h 4.0 2.0  
Exposure:  1 h Comment
Animal  Reading  Erythema Edema  
1 1 h 4 2 Necrosis
2 1 h 4 2 Necrosis
1 24 h 4 2 Necrosis
2 24 h 4 2 Necrosis
1 48 h 4 2 Necrosis
2 48 h 4 2 Necrosis
1 5 d 4 2 Necrosis
2 5 d 4 2 Necrosis
1 8 d 4 2 Necrosis; full thickness
2 8 d 4 2 Necrosis; full thickness
mean (animal 1 & 2) 24 - 48 h 4.0 2.0  

Applicant's summary and conclusion

Interpretation of results:
Category 1A (corrosive) based on GHS criteria