N-ethylpropylamine

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

BASF-Test:
In principle similar to H.F. Smyth et al., Am. Ind. Hyg. Ass. J. 23, 95 - 107, 1962:
The test demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temperature chosen for vapour generation (20 °C). 6 rats per sex were exposed sequentially to the vapours, generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 3 min.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

N-ethylpropylamine

EC Number:

243-573-4

EC Name:

N-ethylpropylamine

Cas Number:

20193-20-8

Molecular formula:

C5H13N

IUPAC Name:

N-ethylpropan-1-amine

Details on test material:

- Name of test material (as cited in study report): Aethylpropylamin
- Physical state: liquid
- Analytical purity: 99 %

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: males: 221 g (mean), females: 193 g (mean)

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

air

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

3 min

Concentrations:

375 mg/L (saturated vapour)

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC100

Effect level:

375 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

3 min

Mortality:

4/12 animals died during the exposure period. 5/12 animals at the end of the exposure and 2 animals 3-4 min post exposure. 1 animal died 2 days post exposure.

Clinical signs:

other: Immediately heavy escape attempts, eyelids closed, wattery and reddish nose discharge, no pain reflex, dyspnoea, bloody nose discharge, cyanosis, corroded noses, apathy, ventral position, corneal opacity, gasping; At the end of exposure squeaking respirat

Body weight:

no data

Gross pathology:

Heart: dilatation, congestion
Lung: acute swelling, distinct pulmonary emphysema