Registration Dossier
Registration Dossier
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EC number: 247-891-4 | CAS number: 26658-19-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature available.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- International Program on Chemical Safety - IPCS - Toxicological evaluation of certain food additives
- Author:
- Croda IPCS WHO
- Year:
- 1 982
- Bibliographic source:
- Twenty sixth report of the Joint FAO/WHO Expert Comittee on Food Additives, Geneva, WHO Tech. Rep. Ser. No. 863, 1982
- Report date:
- 1982
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 947
Materials and methods
- Principles of method if other than guideline:
- intraperitoneal injection of test substance in 10 female rats
- GLP compliance:
- no
Test material
- Reference substance name:
- Sorbitan tristearate
- EC Number:
- 247-891-4
- EC Name:
- Sorbitan tristearate
- Cas Number:
- 26658-19-5
- Molecular formula:
- Molecular formula cannot be given as substance is a mixture.
- IUPAC Name:
- (2R)-2-[(2R,3R,4S)-3,4-bis(octadecanoyloxy)oxolan-2-yl]-2-hydroxyethyl octadecanoate; (2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl octadecanoate; (2R)-2-hydroxy-2-[(2R,3R,4S)-3-hydroxy-4-(octadecanoyloxy)oxolan-2-yl]ethyl (9Z)-octadec-9-enoate
- Details on test material:
- - Name of test material (as cited in study report): sorbitan tristearate
- Analytical purity: 50 % aqueous emulsion form
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 125-175 g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 10 mL/kg bw (50% aqueous emulsion form)
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 48 hours
Results and discussion
- Mortality:
- 2/10 animals died during the first 48 hours after exposure
- Clinical signs:
- Surviving animals did not show any symptoms of toxicity.
- Body weight:
- No data
- Gross pathology:
- No data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
