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EC number: 293-927-7 | CAS number: 91648-65-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- combined repeated dose and reproduction / developmental screening
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- between 16 May 2012 and 20 December 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 421 (Reproduction / Developmental Toxicity Screening Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The Department of Health of the Government of the United Kingdom
Test material
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): 1,3,4-Thiadiazolidine-2,5-dithione, reaction products with hydrogen peroxide and tert-nonanethiol
- Physical state: Liquid
- Expiration date of the lot/batch: 2013-09-05
- Storage condition of test material: Room temperature in the dark
- Other:
Description: Amber coloured liquid
Label: Performance Additive (1,3,4-Thiadiazolidine-2,5-dithione, reaction products with hydrogen peroxide and tert-nonanethiol)
For the purpose of this study the test item was prepared at the appropriate concentrations as a solution in Arachis oil BP. The stability and homogeneity of the test item formulations were determined by Harlan Laboratories Ltd., Shardlow, UK, Analytical Services. Results show the formulations to be stable for at least five weeks. Formulations were therefore prepared fortnightly and stored at approximately 4 ºC in the dark.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories U.K. Ltd., Blackthorn, Bicester, Oxon, UK.
- Age at study initiation: 12 weeks
- Weight at study initiation: males weighed 316 to 357g, the females weighed 193 to 223g
- Fasting period before study: no
- Housing: Initially, all animals were housed in groups of five in solid floor polypropylene cages with stainless steel mesh lids and softwood flake bedding (Datesand Ltd., Cheshire, UK). During the pairing phase, the animals were transferred to polypropylene grid floor cages suspended over trays lined with absorbent paper on a one male: one female basis. Following evidence of successful mating, the males were returned to their original cages. Mated females were housed individually during gestation and lactation, in solid floor polypropylene cages with stainless steel mesh lids and softwood flakes.
- Diet (e.g. ad libitum): ad libitum (a pelleted diet (Rodent 2018C Teklad Global Certified Diet, Harlan Laboratories U.K. Ltd., Oxon, UK))
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 2
- Humidity (%): 55 ± 15
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: between 17 July 2012 (first day of treatment) and 31 August 2012 (final necropsy)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Details on oral exposure:
- The test item was administered daily by gavage using a stainless steel cannula attached to a disposable plastic syringe. Control animals were treated in an identical manner with 4 mL/kg of Arachis oil BP. The volume of test and control item administered to each animal was based on the most recent scheduled body weight and was adjusted at regular intervals.
PREPARATION OF DOSING SOLUTIONS: The volume of test and control item administered to each animal was based on the most recent scheduled body weight and was adjusted at regular intervals.
VEHICLE
- Justification for use and choice of vehicle (if other than water): test material is soluble in arachis oil.
- Concentration in vehicle: 12.5, 62.5 and 250 mg/mL
- Amount of vehicle (if gavage): 4 mL/kg bw - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- Samples of each test item formulation were analysed for concentration of the test material by HPLC. The results indicate that the prepared formulations were within ± 4 % of the nominal concentration.
- Duration of treatment / exposure:
- daily for up to seven weeks (pregnant females were allowed to give birth and maintain their offspring until day 5 post partum. The malles were killed on day 43).
- Frequency of treatment:
- The test item was administered daily.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50, 250 and 1000 mg/kg bw
Basis:
actual ingested
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Dose selection rationale: 14-day oral range-finding in rats, where NOAEL of 1000 mg/kg bw was established (Harlan Laboratories, 2012 Project No. 41200906)
- Positive control:
- No
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
- Time schedule: daily
DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule: All animals were examined for overt signs of toxicity, ill-health and behavioural change immediately before dosing, soon after dosing, and one and five hours after dosing, during the working week. Animals were observed immediately before dosing, soon after dosing, and one hour after dosing at weekends and public holidays (except for females during parturition where applicable). All observations were recorded.
BODY WEIGHT: Yes
- Time schedule for examinations: Individual body weights were recorded on Day 1 (prior to dosing) and then weekly for males until termination and weekly for females until mating was evident. Body weights were then recorded for females on Days 0, 7, 14 and 20 post coitum, and on Days 1 and 4 post partum.
FOOD CONSUMPTION: Yes
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: Yes
During the pre-pairing period, weekly food consumption was recorded for each cage of adults until pairing. This was continued for males after the mating phase. For females showing evidence of mating, food consumption was recorded for the periods covering post coitum Days 0-7, 7-14 and 14-20. For females with live litters, food consumption was recorded during the lactation period (Days 1-4).
- Compound intake calculated as time-weighted averages from the consumption and body weight gain data: Yes (as g/rat/day)
Weekly food efficiency (body weight gain/food intake) was calculated retrospectively for males and for females during the pre-pairing phase. Due to offspring growth and milk production for lactation, food efficiency for females could not be accurately calculated for females during gestation and lactation.
WATER CONSUMPTION: Yes
- Time schedule for examinations: daily ((with the exception of the pairing phase).
HAEMATOLOGY: No
CLINICAL CHEMISTRY: No
URINALYSIS: No
NEUROBEHAVIOURAL EXAMINATION: No
OTHER: Reproductive and developmental parameters (see section 7.8.1) - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
Adult males were killed by intravenous overdose of a suitable barbiturate agent followed by exsanguination on Day 43. Adult females were killed by intravenous overdose of a suitable barbiturate agent followed by exsanguination on Day 5 post partum. Any females which failed to achieve pregnancy or produce a litter were killed on or after Day 25 post coitum.
For all females, the uterus was examined for signs of implantation and the number of uterine implantations in each horn was recorded. This procedure was enhanced; as necessary, by staining the uteri with a 0.5 % ammonium polysulphide solution.
All adult animals, including those dying during the study, were subjected to a full external and internal examination, and any macroscopic abnormalities were recorded.
The epididymides and testes were removed from terminal kill adult males dissected free
from fat and weighed before fixation.
HISTOPATHOLOGY: Yes
Histopathology:
Samples of the following tissues were preserved from all animals from each dose group, in buffered 10 % formalin, except where stated:
Coagulating gland
Prostate
Epididymides♦
Seminal vesicles
Gross Lesions
Testes♦
Ovaries
Uterus/Cervix
Mammary gland (females only)
Vagina
Pituitary
♦ = preserved in Bouin’s fluid then transferred to 70 % Industrial Methylated Spirits (IMS) approximately forty-eight hours later
All tissues were despatched to the Test Site for processing. The tissues from control and 1000 mg/kg bw/day dose group animals, any animals dying during the study, and any animals which failed to mate or did not achieve a pregnancy were prepared as paraffin blocks, sectioned at a nominal thickness of 5 μm and stained with Haematoxylin and Eosin for subsequent microscopic examination. In addition, sections of testes and epididymides from all control and 1000 mg/kg bw/day males were also stained with Periodic Acid-Schiff (PAS) stain and examined.
Since there were indications of treatment related kidney changes, examination was subsequently extended to include similarly prepared sections of kidney from animals from the low and intermediate groups.
Microscopic examination was conducted by the Study Pathologist. - Other examinations:
- Reproductive performance and litter observations (see section 7.8.1)
- Statistics:
- Where considered appropriate, quantitative data was subjected to statistical analysis to detect the significance of intergroup differences from control; statistical significance was achieved at a level of p < 0.05. Statistical analysis was performed on the following parameters:
Body Weight, Body Weight Change, Food Consumption during gestation and lactation, Water Consumption during gestation and lactation, Pre-Coital Interval, Gestation Length, Litter Size, Litter Weight, Sex Ratio, Corpora Lutea, Implantation Sites, Implantation Losses, Viability Indices, Offspring Body Weight, Offspring Body Weight Change, Offspring Surface Righting, Absolute Organ Weights, Body Weight-Relative Organ Weights.
Data were analysed using the decision tree from the ProvantisTM Tables and Statistics Module as detailed below:
Where appropriate, data transformations were performed using the most suitable method. The homogeneity of variance from mean values was analysed using Bartlett’s test. Intergroup variance were assessed using suitable ANOVA, or if required, ANCOVA with appropriate covariates. Any transformed data were analysed to find the lowest treatment level that showed a significant effect, using the Williams Test for parametric data or the Shirley Test for non-parametric data. If no dose response was found, but the data shows non-homogeneity of means, the data were analysed by a stepwise Dunnett’s (parametric) or Steel (non-parametric) test to determine significant difference from the control group. Where the data were unsuitable for these analyses, pair-wise tests was performed using the Student t-test (parametric) or the Mann-Whitney U test (non-parametric).
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- no effects observed
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- revealed mottled kidneys, enlarged kidneys and/or pale kidneys in males (all dose groups) and
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- hyaline droplets accumulation in proximal tubules, tubular degeneration and regeneration of the proximal convoluted tubules, granular casts in the inner portion of cortex and medulla, interstitial fibrosis and mixed cell infiltration
- Histopathological findings: neoplastic:
- no effects observed
- Details on results:
- CLINICAL SIGNS AND MORTALITY
There were no toxicologically significant clinical signs detected in treated animals. Animals of either sex treated with 1000 and 250 mg/kg bw/day and males treated with 50 mg/kg bw/day showed episodes of increased salivation from Day 11 onwards. Observations of this nature are commonly observed following the oral administration of an unpalatable or slightly irritant test item formulation and in isolation is considered not to be of toxicological importance.
BODY WEIGHT AND WEIGHT GAIN
There were no toxicologically significant effects detected in body weight development. Males treated with 1000 mg/kg bw/day showed a statistically significant increase in body weight gain during the final week of treatment. An increase in body weight gain is considered not to represent an adverse effect of treatment therefore the intergroup difference was considered not to be of toxicological importance.
FOOD CONSUMPTION AND COMPOUND INTAKE
No adverse effect on food consumption or food efficiency was detected in treated animals when compared to control animals.
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study)
No toxicologically significant effect on water consumption was detected. Males treated with 1000 and 250 mg/kg bw/day showed an increase in overall water consumption compared to control animals. Females treated with 1000 mg/kg bw/day also showed an increase in water consumption throughout maturation and gestation. Observations of this nature are commonly observed following the oral administration of an unpalatable or slightly irritant test item formulation and in isolation the intergroup differences were considered not to be of toxicological importance.
ORGAN WEIGHTS
There were no treatment-related effects on absolute or relative organ weights. Statistical analysis of the data did not reveal any significant intergroup differences.
GROSS PATHOLOGY
All males treated with 1000 mg/kg bw/day had mottled kidneys, seven of which also had enlarged and pale kidneys, one male also had enlarged kidneys and one male also had pale kidneys. One female treated with 1000 mg/kg bw/day had pale kidneys. Seven males treated with 250 mg/kg bw/day and one male treated with 50 mg/kg bw/day had mottled kidneys. No such effects were detected in females treated with 50 mg/kg bw/day.
HISTOPATHOLOGY: NON-NEOPLASTIC
Kidneys: Males from all treatment groups showed treatment-related lesions characterized by hyaline droplets accumulation in the cytoplasm of the proximal convoluted tubules, tubular degeneration and regeneration of the proximal convoluted tubules, granular casts in the inner portion of cortex and medulla, interstitial fibrosis and mixed cell infiltration. The severity of the lesions was dose-proportional. It is likely that the degenerative / regenerative and inflammatory lesions were secondary to the hyaline droplet accumulation in the cytoplasm of the tubular epithelium. In females treated with 1000 mg/kg bw/day, the nature of the kidneys lesions was different. Tubular vacuolation of the proximal portion was evident in two females and in one of these females which was affected more severely; it was associated to a minimal single cell necrosis of the epithelium.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 250 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: kidney effects at the highest dose level.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Table 1. Incidence and Mean Severity Grade of Kidneys Findings | ||||||||
Males | Females | |||||||
Group |
1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 |
Animals and Tissues Examined |
10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
Tub.Degen/Regenerat. |
0 | 6 | 10 | 10 | 0 | 0 | 0 | 0 |
Mean Severity |
0 | 1.2 | 2.2 | 3.5 | 0 | 0 | 0 | 0 |
Mixed Cell Infiltration |
1 | 0 | 8 | 10 | 1 | 0 | 0 | 2 |
Mean Severity |
1.0 | 0 | 1.8 | 2.6 | 1.0 | 0 | 0 | 1.0 |
Interst. Fibrosis |
0 | 0 | 7 | 10 | 0 | 1 | 0 | 0 |
Mean Severity |
0 | 0 | 1.6 | 2.5 | 0 | 1.0 | 0 | 0 |
Tubular Basophilia |
1 | 1 | 0 | 0 | 3 | 0 | 1 | 3 |
Mean Severity |
1.0 | 1.0 | 0 | 0 | 1.0 | 0 | 1.0 | 1.3 |
Hyaline Droplets |
1 | 10 | 10 | 10 | 0 | 0 | 0 | 0 |
Mean Severity |
1.0 | 1.6 | 2.7 | 3.6 | 0 | 0 | 0 | 0 |
Granular Casts |
0 | 0 | 10 | 10 | 0 | 0 | 0 | 0 |
Mean Severity |
0 | 0 | 1.9 | 2.8 | 0 | 0 | 0 | 0 |
Hyaline Casts |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Mean Severity |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.0 |
Tubular Vacuolation |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
Mean Severity |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.5 |
Tub. Single Cell Necrosis |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Mean Severity |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.0 |
Grading:
Grade 1 = Minimal Grade
2 = Slight Grade
3 = Moderate
Grade 4 = Marked
No treatment-related effects were detected in the reproductive organs examined.
Applicant's summary and conclusion
- Conclusions:
- The NOAEL of 250 mg/kg bw was established for females. Excluding species specific effects (kidney degeneration as the result of hyaline droplets accumulation in tubulis) in males, which are not relevant for humans, the systemic NOAEL for males is 1000 mg/kg bw.
- Executive summary:
An Oral (gavage) reproduction/developmental toxicity screening test in the rat wasperformed in order to investigate potential adverse effects of 1,3,4-Thiadiazolidine-2,5-dithione, reaction products with hydrogen peroxide and tert-nonanethiol on reproduction including offspring development (OECD 421, Harlan Laboratories, 2013). The test item was administered by oral gavage to three groups, each of ten male and ten female Wistar Han™:RccHan™:WIST strain rats, for up to seven weeks (including a two week pre-pairing phase, pairing, gestation and early lactation for females), at dose levels of 50, 250 and 1000 mg/kg bw/day. A control group of ten males and ten females was dosed with vehicle alone (Arachis oil BP). Clinical signs, body weight change, dietary intake and water consumption were monitored during the study. Pairing of animals within each dose group was undertaken on a one male: one female basis within each treatment group on Day 15 of the study, with females subsequently being allowed to litter and rear their offspring to Day 5 of lactation. During the lactation phase, daily clinical observations were performed on all surviving offspring, together with litter size and offspring weights and assessment of surface righting reflex.Adult males were killed by intravenous overdose of a suitable barbiturate agent followed by exsanguination on Day 43. Adult females were killed by intravenous overdose of a suitable barbiturate agent followed by exsanguination on Day 5 post partum. Surviving offspring were terminated via intracardiac overdose of sodium pentobarbitone. Any females which failed to achieve pregnancy or produce a litter were killed on or after Day 25 post coitum. For all females, the uterus was examined for signs of implantation and the number of uterine implantations in each horn was recorded. This procedure was enhanced; as necessary, by staining the uteri with a 0.5 % ammonium polysulphide solution (Salewski 1964, cited in the study report). All adult animals and offspring, including those dying during the study, were subjected to a full external and internal examination, and any macroscopic abnormalities were recorded.Any female which did not produce a pregnancy was terminated on or after Day 25 post coitum. All animals were subjected to a gross necropsy examination and histopathological evaluation of reproductive tissues was performed.
There were no unscheduled deaths and toxicologically significant clinical signs detected in treated animals. Body weight development, food and water consumption were unaffected. Regarding reproductive performance, no treatment-related effects were recorded on mating and conception rates. There were differences in gestation length. The distribution for treated females was comparable to controls. The gestation lengths were between 22 and 23 ½ days for each group. The following parameters of litters born were comparable to controls: litter size, body weight gain and litter weights and sex ratio at birth and subsequently on Days 1 and 4 post partum. The surface righting reflex of the live offspring (Day 1 post partum was also comparable to controls and no clinically observable signs of toxicity were detected.
At necropsy,males treated with 1000 mg/kg bw/day had mottled kidneys, seven of which also had enlarged and pale kidneys, one male also had enlarged kidneys and one male also had pale kidneys. One female treated with 1000 mg/kg bw/day had pale kidneys. Seven males treated with 250 mg/kg bw/day and one male treated with 50 mg/kg bw/day had mottled kidneys. No such effects were detected in females treated with 250 or 50 mg/kg bw/day. There were no treatment-related effects on absolute or relative organ weights. Statistical analysis of the data did not reveal any significant intergroup differences. At the histopathological evaluation, the following treatment related microscopic abnormalities were detected in the kidneys: males from all treatment groups showed treatment-related lesions characterized by hyaline droplet accumulation in the cytoplasm of the proximal convoluted tubules, tubular degeneration and regeneration of the proximal convoluted tubules, granular casts in the inner portion of cortex and medulla, interstitial fibrosis and mixed cell infiltration. The severity of the lesions was dose-proportional. It is likely that the degenerative / regenerative and inflammatory lesions were secondary to the hyaline droplet accumulation in the cytoplasm of the tubular epithelium. In females treated with 1000 mg/kg bw/day, the nature of the kidneys lesions was different. Tubular vacuolation of the proximal portion was evident in two females and in one of these females which was affected more severely; it was associated with a minimal single cell necrosis of the epithelium.
In conclusion, the oral administration of 1,3,4-Thiadiazolidine-2,5-dithione, reaction products with hydrogen peroxide and tert-nonanethiol to rats by gavage, at dose levels of 50, 250 and 1000 mg/kg bw/day, resulted in treatment related microscopic kidney effects in males from all treatment groups and in females treated with 1000 mg/kg bw/day. No such effects were detected in females treated with 50 or 250 mg/kg bw/day.
Therefore, the “No Observed Effect Level” (NOEL) for systemic toxicity is 250 mg/kg bw/day in females. In males, the kidney effects detected in all treatment groups were considered to represent an adverse effect of the test item, therefore a ‘No Observed Adverse Effect Level’ (NOAEL) has not been established in the male rat. However, the kidney changes of hyaline droplets were consistent with well documented changes that are peculiar to the male rat in response to treatment with some hydrocarbons (Alden 1986, Hard, 2008, cited in the study report). This effect is, therefore, not indicative of a hazard to human health. In the context of this study, the remaining kidney findings consisting of tubular degeneration/regeneration, granulated tubular casts, interstitial fibrosis and mixed cell infiltration in males are more likely to be correlated to the same condition as hyaline droplets and are therefore considered to represent limited relevance to humans. In terms of extrapolation to man and risk assessment calculations whereby effects relating to male rat renal changes are species and sex specific and therefore are not relevant, a NOAEL for males can be established at 1000 mg/kg bw/day. The NOEL for reproductive toxicity and regarding neonatal toxicity was 1000 mg/kg bw/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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