Registration Dossier
Registration Dossier
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EC number: 206-370-1 | CAS number: 333-20-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline was not followed, methods were not available at the time of the study. The study was performed pre-GLP.
Data source
Reference
- Reference Type:
- publication
- Title:
- Absorption and toxicity of sodium and potassium thiocyanates
- Author:
- Anderson, R.C., Chen K.K.
- Year:
- 1 940
- Bibliographic source:
- J Amer Pharmac Assoc 29 (1940) 152-161
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Sodium thiocyanate
- EC Number:
- 208-754-4
- EC Name:
- Sodium thiocyanate
- Cas Number:
- 540-72-7
- IUPAC Name:
- sodium thiocyanate
- Details on test material:
- Sodium thiocyanate.
Recrystallized from water, and the moisture content determined. The water of crystallization of the sodium constituted 3.525 per cent. All the doses were calculated according to the anhydrous forms.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- Doses:
- 453, 482, 521, 579 mg/kg bw
- No. of animals per sex per dose:
- 5 or 6 or 7, sex undefined
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 483.5 mg/kg bw
- Remarks on result:
- other: standard deviation 9.3
- Mortality:
- Dose: 453, 482, 521, 579 mg/kg bw
Deaths: 0/6, 5/7, 4/5, 5/5
Any other information on results incl. tables
potassium thiocyanate by intravenous injection is more than five times as toxic as sodium thiocyanate to mice when their median lethal doses (L. D.m) are compared. Clonic convdsions, gasping and deaths occurred within 2 to 3 minutes with the potassium salt, while the same were delayed with the sdoium salt for 1 -3 hours. The highly toxic action of the potassium ions upon the heart undoubtly accounted for the differnce. In case of oral doses the toxicity between the two compounds differs slightly.
Applicant's summary and conclusion
- Conclusions:
- The LD50 in mice after i.v. administration is 483.5 ± 9.3 mg/kg bw.
- Executive summary:
An acute toxicity study was performed pre-GLP and pre-guideline. The LD50 in mice after i.v. admniistration is 483.5 ± 9.3 mg/kg bw.
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