Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 92/69/EEC, B.3
GLP compliance:
yes
Limit test:
no

Test animals

Species:
other: rat, Wistar HsdCpb:Wu

Administration / exposure

Type of coverage:
semiocclusive
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
No systemic effects were observed.
Gross pathology:
Effects on organs:
The necropsies performed at the end of the study revealed no
particular findings.
Other findings:
Signs of toxicity (local):
A dose of 2000 mg/kg body weight was tolerated by males and
females without toxicologically relevant clinical signs.
Locally, a partial beige discoloration of the treatment area
was observed. The most plausible interpretation is a
discoloration by the light brown color of the test compound
(which is not considered a toxicologically relevant effect).


There were no toxicological effects on body weight or body
weight development in males and females. The slight decrease
in body weight gain of three females in the first week is
assumed to be caused by the stress of the application
procedure, and is not considered test compound related.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU