Registration Dossier
Registration Dossier
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EC number: 604-582-2 | CAS number: 1472-93-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- Pow
- Partition coefficient:
- 36 300 000
- Temp.:
- 40 °C
- Remarks on result:
- other: HPLC method
- Type:
- log Pow
- Partition coefficient:
- 7.56
- Temp.:
- 40 °C
- Remarks on result:
- other: HPLC method
- Conclusions:
- The partition coefficient of the test material was assessed according to OECD Guideline 117 and determined to be 3.63 x 10E7, log10 Pow 7.56.
- Executive summary:
The partition coefficient of the test substance was determined to be 3.98 x 104, log10Pow, using the HPLC method, designed to be compatible with method A8 partition coefficient of commission regulation (EC) No 440/2008 of 30 May 2008 and method 117 of the OECD guidelines for testing of chemicals, 13 April 2004 (Harlan Laboratories Ltd, 2013).
Reference
Preliminary estimated result (using KOWWIN v1.67a): 7.28
Definitive test:
The retention times, capacity factor and log10Pow value determined for the sample are shown in the following table:
Injection |
Retention Time (mins) |
Capacity Factor (Kâ) |
Log10Kâ |
Log10Pow |
1 |
8.508 |
1.17 |
1.07 |
7.56 |
2 |
8.537 |
1.17 |
1.07 |
7.56 |
Description of key information
The partition coefficient of the test material was assessed according to OECD Guideline 117, using the HPLC method, and determined to be 3.63 x 107, log10 Pow 7.56.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 7.56
- at the temperature of:
- 40 °C
Additional information
The partition coefficient of the test substance was determined to be 3.98 x 104, log10Pow, using the HPLC method, designed to be compatible with method A8 partition coefficient of commission regulation (EC) No 440/2008 of 30 May 2008 and method 117 of the OECD guidelines for testing of chemicals, 13 April 2004 (Harlan Laboratories Ltd, 2013).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
