Registration Dossier
Registration Dossier
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EC number: 213-497-6 | CAS number: 959-26-2
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental start date 28th April 2021. Experimental completion date 28th April 2021.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method A.24 (Partition Coefficient (n-Octanol/Water), High Performance Liquid Chromatography (HPLC) Method)
- Version / remarks:
- 2015
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 2004
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Name: BHET
Batch no.: AWS0274J
Purity: ~95% - Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- < 1.6
- Temp.:
- 25 °C
- Remarks on result:
- other: Test item is assumed to consist of 2 peaks. The highest log Pow for peak 2 is reported here.
- Details on results:
- It is assumed that the test item consist of two peaks.
The first peak eluted with a retention time slightly before the reference item with the lowest log Pow (log Pow 0.3). The log Pow was extrapolated to -0.114 ± 0.0. A calculated value by EPISuite gives a log Pow of 0.12. Since both the extrapolated value and the values obtained by EPISuite are < 0.3, the log Pow for this first peak is stated as < 0.3.
The second peak eluted within the calibration range with a log Pow of 1.587.
The log Pow for the test item is reported as < 0.3 to 1.6. - Conclusions:
- The log Pow of the test item is stated as < 0.3 - 1.6.
- Executive summary:
The log Pow was assessed following the HPLC method according to GLP. The test item is assumed to elute with 2 peaks.
Peak 1: log Pow was outside of the calibration range and is reported as < 0.3
Peak 2: log Pow was within the calibration range and is reported as 1.6
The log Pow for the test item is between < 0.3 and 1.6.
Reference
Description of key information
The test item is assumed to elute with two peaks. The log Pow for the test item is between < 0.3 and 1.6. The log Pow used for the Risk Assessment is the maximum value of 1.6.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.6
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
