1-(3-(4-fluorophenoxy)propyl)-3-methoxy-4-piperidinone

Hydrolysis

Administrative data

Endpoint:

hydrolysis

Adequacy of study:

other information

Data source

Reference

Reference Type:

other:

Title:

Unnamed

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other:

Results and discussion

Dissipation DT50 of parent compound

Dissipation DT50 of parent compound 1

pH:

7

Temp.:

50 °C

Hydrolysis rate constant:

1 600 s-1

DT50:

1 200 h

Dissipation DT50 of parent compound 2

pH:

7

Temp.:

25 °C

Hydrolysis rate constant:

1 400 s-1

DT50:

13 752 h

Dissipation DT50 of parent compound 3

pH:

7

Temp.:

60 °C

Hydrolysis rate constant:

4 500 s-1

DT50:

432 h

Dissipation DT50 of parent compound 4

pH:

7

Temp.:

70 °C

Hydrolysis rate constant:

8 800 s-1

DT50:

216 h

Dissipation DT50 of parent compound 5

pH:

9

Temp.:

50 °C

Hydrolysis rate constant:

1 100 s-1

DT50:

1 800 h

Dissipation DT50 of parent compound 6

pH:

9

Temp.:

60 °C

Hydrolysis rate constant:

3 700 s-1

DT50:

528 h

Dissipation DT50 of parent compound 7

pH:

9

Temp.:

70 °C

Hydrolysis rate constant:

800 s-1

DT50:

240 h