Adenosine 5'-(trihydrogen diphosphate), monopotassium salt

Stability: thermal, sunlight, metals

Administrative data

Endpoint:

thermal stability

Type of information:

experimental study

Adequacy of study:

key study

Study period:

26 - 30 November 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2021

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

other: UN Manual of Tests and Criteria

Version / remarks:

7th edition

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 113 (Screening Test for Thermal Stability and Stability in Air)

Version / remarks:

1981

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

Adenosine 5'-(trihydrogen diphosphate), monopotassium salt

EC Number:

274-533-4

EC Name:

Adenosine 5'-(trihydrogen diphosphate), monopotassium salt

Cas Number:

70285-70-0

Molecular formula:

C10H14KN5O10P2

IUPAC Name:

potassium;[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate

impurity 1

Reference substance name:

Water

EC Number:

231-791-2

EC Name:

Water

Cas Number:

7732-18-5

Molecular formula:

H2O

IUPAC Name:

Oxidane

impurity 2

Reference substance name:

Sum of impurities from ADP, K (each < 1 %)

IUPAC Name:

Sum of impurities from ADP, K (each < 1 %)

Test material form:

solid: particulate/powder

Details on test material:

Batch No.: 37779100
Storage Conditions: Refrigerator (approx. 2 °C to 8 °C)

Specific details on test material used for the study:

Batch No.: 37779100
Storage Conditions: Refrigerator (approx. 2 °C to 8 °C)

Results and discussion

For thermal stability study

Test substance thermally stable:

yes

Operating temperature

Key result

Operating temp.:

ca. 20 - <= 500 °C

Remarks on result:

other: The test item showed two exothermic effects starting at temperatures of 130 °C and 240 °C, respectively, with average energy releases of -460 J/g and -120 J/g

Any other information on results incl. tables

The test item in closed gold-plated stainless-steel crucibles showed two exothermic effects starting at temperatures of 130 °C and 240 °C, respectively, with average energy releases of -460 J/g and -120 J/g. The results of the DSC-measurements are summarized in the table below:

 

No.	Sample weight / mg	Onset / °C	Energy / J/g
PN20555	4.16	130 240	-450  (exothermic) -110  (exothermic)
PN20562	4.37	140 240	-460  (exothermic) -120  (exothermic)

Applicant's summary and conclusion

Conclusions:

The test item Adenosine 5'-diphosphate monopotassium salt (dried) (CAS no. 70285-70-0) showed two exothermic effects starting at temperatures of 130 °C and 240 °C, respectively, with average energy releases of -460 J/g and -120 J/g.

Executive summary:

The test item Adenosine 5'-diphosphate monopotassium salt (dried) (CAS no. 70285-70-0) showed two exothermic effects starting at temperatures of 130 °C and 240 °C, respectively, with average energy releases of -460 J/g and -120 J/g.

Due to the fact that the decomposition energy of the exothermic effects is greater than -300 J/g and the onset of the first exothermix effect started below 200 °C, self-reactive properties cannot be excluded.

Since the overall decomposition energy of the exothermic effects goes above the threshold of -500 J/g, explosive properties also cannot be excluded.