Registration Dossier
Registration Dossier
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EC number: 854-058-4 | CAS number: 58625-89-1
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
A 72-h ErC50 and ErC10 values are 2.86 and 1.05 mg/L, respectively, based on ECOSAR prediction using the determined log Kow of 3.1.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 2.86 mg/L
- EC10 or NOEC for freshwater algae:
- 1.05 mg/L
Additional information
The acute algae ErC50 for the ester Ethyl 2-methyl-3-pentenoate is predicted to be 2.86 mg/l based on the ECOSAR SAR for esters using a measured log Kow of 3.1, molecular weight of 142 and the equation: Log 96-h EC50 (mmol/L) = -0.6993 (log Kow) + 0.4715. The 96-h EC50 is considered equivalent to the 72h current exposure time in the OECD TG 201 test.
The algae EC10 for the ester Ethyl 2-methyl-3-pentenoate is predicted to be 1.05 mg/l based on the ECOSAR SAR for esters using a measured log Kow of 3.1, molecular weight of 142 and the equation: Log 96h ChV (mmol/L) = -0.5583 (log Kow) - 0.4017. The ChV is considered equivalent to the EC10 in the OECDTG 201 test.
Ethyl 2-methyl-3-pentenoate is in the applicability domain of the ECOSAR prediction because: a) The substance is an ester presenting the toxicity solely by its bioavailability; b) its measured log Kow is 3.1 (=< 6.4); c) its MW is 142 (< 1000); and; d) the toxicity predicted is below its water solubility of 613 mg/l.
The measured and predicted log Kows of the substance are 3.1 and 2.54. In view of the difference being > 0.5, the measured log Kow of 3.1 is used presenting a conservative value (a lower EC50).
In accordance with REACH Annex XI, the validity of the (Q)SAR is documented in a QMR for acute algae toxicity on esters (see attached reports). The adequate and reliable documentation, presented, further supports this prediction.
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