Registration Dossier
Registration Dossier
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EC number: 221-650-3 | CAS number: 3177-22-8
Endpoint summary
Administrative data
Description of key information
Low aquatic toxicity.
Additional information
No experimental data is available on target substance, i.e. sodium salt.
An experimental data is available on a structural analogue, i.e. 4-aminobenzenesulphonic acid (CAS 121-57-3,EC 204-482-5); based on the structural similarity, it is considered as representative of the target substance. In particular, fish toxicity was assessed on Fathead Minnow in a 96 -hour, static test in freshwater. Based on a mortality effect, LC50 of 100.4 mg/l was found (ref. Journal of Hydrology, Volume 51, Issues 1–4, May 1981, pp. 359-367, Aquatic toxicity of forty industrial chemicals: Testing in support of hazardous substance spill prevention regulation, M.W. Curtis, C.H. Ward).
Short-term and chronic toxicity of target substance to aquatic species, i.e. fish, daphnid and green algae, was evaluated by means of ECOSAR v2.0 tool. The target substance was attributed to two ECOSAR classes, based on the molecular structure: anilines unhindered and meta-amino anilines. In all cases, predicted effect concentrations for short-term exposure were above the threshold of 100 mg/l for classification within the CLP Regulation (EC 1272/2008). Similarly, chronic values were above the threshold of 1 mg/l for classification within the CLP Regulation (EC 1272/2008).
Low toxicity to fish was also predicted by Vega-qsar tool for another structural analogue of target substance, i.e. its acid form (CAS 88 -63 -1, EC 201 -846 -5). In particular, a predicted LC50 value of 437.52 mg/l is reported by the Fathead Minnow LC50 96h (EPA) 1.0.7 tool.
Further details are available in the attachment in IUCLID section 13.2.
Based on available information, no classification for aquatic toxicity within the CLP Regulation (EC 1272/2008) is proposed for target substance.
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