Petroleum kerosene fraction, co-processed with renewable hydrocarbons of plant and/or animal origin

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: This study is classified as reliable without restrictions because it was carried out in a method equivalent/similar to OECD TG 401.

Justification for type of information:

Read across justification included in Section 13

Cross-reference

Reason / purpose for cross-reference:

read-across: supporting information

Reference

Endpoint:

acute toxicity: oral

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: This study is classified as reliable without restrictions because it was carried out in a method equivalent/similar to OECD TG 401.

Justification for type of information:

Read across justification included in Section 13

Reason / purpose for cross-reference:

read-across source

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Route of administration:

oral: gavage

Vehicle:

other: Undiluted

Doses:

Single dose level of 5000 mg/kg

No. of animals per sex per dose:

Five

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

No deaths resulted. Main clinical signs were hypoactivity, excess salivation, diarrhoea, urine-stained abdomen and hair loss around the anal area. At necropsy, the only visible finding was kidney distension in one male animal.

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LD50 was greater than 5000 mg/kg.

Executive summary:

The acute oral toxicity of hydrodesulfurised kerosine was studied in 5 male and 5 female albino Sprague-Dawley rats. Animals weighing 188-330g received a single dose of 5000 mg/kg by oral gavage and were observed for clinical signs and mortality at hourly intervals during the first 6 hours after administration. Thereafter animals were observed twice daily for 14 days. At termination of the study, all animals were sacrificed and subjected to gross necropsy examination. Clinical signs observed throughout the study include hypoactivity, excess salivation, diarrhoea, urine stained abdomen and hair loss around the anal area. No mortality was observed. The LD50 for hydrodesulfurised kerosine was > 5000 mg/kg.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1982

Report date:

1982

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

Kerosine (petroleum), hydrodesulfurized

EC Number:

265-184-9

EC Name:

Kerosine (petroleum), hydrodesulfurized

Cas Number:

64742-81-0

IUPAC Name:

Kerosine (petroleum), hydrodesulfurized

Constituent 2

Reference substance name:

Hydrodesulfurised kerosine

IUPAC Name:

Hydrodesulfurised kerosine

Test material form:

other: low viscosity liquid hydrocarbon

Details on test material:

- Name of test material (as cited in study report): Hydrodesulfurised kerosine, CAS No. 64742-81-0
- Lot/batch No.: API 81-07

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: Undiluted

Doses:

Single dose level of 5000 mg/kg

No. of animals per sex per dose:

Five

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Any other information on results incl. tables

No deaths resulted. Main clinical signs were hypoactivity, excess salivation, diarrhoea, urine-stained abdomen and hair loss around the anal area. At necropsy, the only visible finding was kidney distension in one male animal.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LD50 was greater than 5000 mg/kg.

Executive summary:

The acute oral toxicity of hydrodesulfurised kerosine was studied in 5 male and 5 female albino Sprague-Dawley rats. Animals weighing 188-330g received a single dose of 5000 mg/kg by oral gavage and were observed for clinical signs and mortality at hourly intervals during the first 6 hours after administration. Thereafter animals were observed twice daily for 14 days. At termination of the study, all animals were sacrificed and subjected to gross necropsy examination. Clinical signs observed throughout the study include hypoactivity, excess salivation, diarrhoea, urine stained abdomen and hair loss around the anal area. No mortality was observed. The LD50 for hydrodesulfurised kerosine was > 5000 mg/kg.