3,5,5-trimethylcyclohex-2-enone

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

publication

Title:

Further studies on sensory response to certain industrial solvent vapors

Author:

L. Silverman, H.F. Schulte and M.W. First

Year:

1946

Bibliographic source:

Ind. Hyg. Toxicol.

Materials and methods

Type of study / information:

- highest concentration which majority of subjects estimated satisfactory for 3-hour exposure
- concentration of vapor which irritated majority of subjects
- suggested maximum allowable concentration

Endpoint addressed:

respiratory irritation

Test guideline

Qualifier:

no guideline required

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3,5,5-trimethylcyclohex-2-enone

EC Number:

201-126-0

EC Name:

3,5,5-trimethylcyclohex-2-enone

Cas Number:

78-59-1

Molecular formula:

C9H14O

IUPAC Name:

3,5,5-trimethylcyclohex-2-enone

Method

Ethical approval:

not specified

Details on study design:

- An average number of twelve subjects of both sexes were used.
- The time of exposure was 15 minutes.
- During the 15 minute exposure period, motion pictures were shown to occupy the subjects' attention and divert their thoughts from the atmospheric contamination to which they were exposed.

Exposure assessment:

not specified

Results and discussion

Results:

25 ppm will produce irritation of the eyes, nose, and throat in human subjects. The majority of subjects were not uncomfortable at 10 pppm. 70% of the subjects objected to the odor at 25 ppm, and only 40% objected to the odor at 10 ppm. The test substance has an odor strongly resembling camphor.