Registration Dossier
Registration Dossier
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EC number: 701-365-5 | CAS number: -
Endpoint summary
Administrative data
Description of key information
The test substance has a very high water solubility. Screening tests for biodegradation of the test substance in water showed that the test substance is not readily biodegradable. However, it is rapidly hydrolysed with a half-life of 1 to 2 days at pH 7. When the test substance was applied to a sediment/water test system at a final concentration of 1 mg/kg in the test system, the test substance was rapidly degraded. The DT50 of the test substance was 2 days. After 3 to 6 days, only 10 % of the applied test substance could be found. All metabolites decreased at the end of the test period to levels about the lowest level of quantification. Consequently, an accumulation of metabolites could be excluded. The majority of the metabolites of the test substance was deposited in form of non-extractable residues in sediment during test phase. After about 1 month, mineralization of the metabolites started.
A bioaccumulation study in the carp revealed bioconcentration factors <11 for 0.2 mg/L and <1.1 for 2 mg/L. Hence, the test substance does not bioaccumulate in the aquatic compartment. Based on data from kinetic and metabolism studies in rats (oral and intravenous administration), the test substance does not have any bioaccumulation potential in animals. Due to the very low toxicity, rapid degradation and lack of bioaccumulative properties, secondary poisoning can be excluded.
Under the recommended conditions of use no exposure to soil is to be expected.
Conclusion: slow but not readily biodegradation, substance is hydrolysed at pH 7 no indication of bioaccumulation, no indication of secondary poisoning; no reason to perform tests on soil or sediment
Additional information
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