Registration Dossier
Registration Dossier
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EC number: 854-355-9 | CAS number: 428854-23-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The mutagenic potential of the test material was evaluated in a Salmonella/microsome test with the S. typhimurium strains TA 98, TA 100, TA 102, TA 1535 and TA 1537 in the presence and absence of S9 mix according to OECD TG 471. Doses up to and including 1600 µg per plate caused bacteriotoxic effects, evident from a dose-dependent decrease of the mutant count per plate.Test item precipitation did not occur. The positive controls increased mutant counts to well over those of the solvent controls, and thus demonstrated the system's sensitivity and the activity of the S9 mix. None of the five strains used showed a dose-related and biologically relevant increase in mutant counts over those of the solvent controls in the preincubation test. This applied both to the tests with and without S9 mix. Due to these results the test item has to be regarded as non-mutagenic.
Justification for classification or non-classification
Based on the study result for Genetic toxicity in vitro no classification according to Regulation (EC) No. 1272/2008 (CLP), ANNEX I, is warranted.
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