Registration Dossier
Registration Dossier
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EC number: 924-436-4 | CAS number: 68038-65-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 9 Days
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 430 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER))
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Bacillus Ferment Filtrate Extract
- EC Number:
- 924-436-4
- Cas Number:
- 68038-65-3
- Molecular formula:
- Not Available
- IUPAC Name:
- Bacillus Ferment Filtrate Extract
- Test material form:
- liquid
Constituent 1
In vitro test system
- Test system:
- isolated skin discs
- Source species:
- rat
- Cell type:
- other: Skin Discs
- Cell source:
- other: Sacrificed rat skin discs
- Source strain:
- Wistar
- Vehicle:
- water
- Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- Duration of treatment / exposure:
- 24 hours
- Number of replicates:
- 3
Test animals
- Species:
- rat
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- water
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- transcutaneous electrical resistance (in kΩ)
- Value:
- >= 6.34 - <= 6.34
- Vehicle controls validity:
- not valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: Non-Corrosion
Applicant's summary and conclusion
- Interpretation of results:
- other: Non-Corrosive
- Conclusions:
- The InVitro study of Bacillus Coagulans was found to be Non-Corrosive by Transcutaneous Electrical Resistance (TER) method.
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