Reaction products of triphenyl phosphite and isodecanol (1:1)

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1975

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

EPA OPP 81-5 (Acute Dermal Irritation)

Principles of method if other than guideline:

US 1964 guideline used - Federal Register 191.11, 17 September 1964.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Phosphorous acid, diphenyl isodecyl ester

Molecular formula:

C22H31O3P

IUPAC Name:

Phosphorous acid, diphenyl isodecyl ester

Constituent 2

Reference substance name:

Triphenyl phosphite

EC Number:

202-908-4

EC Name:

Triphenyl phosphite

Cas Number:

101-02-0

Molecular formula:

C18H15O3P

IUPAC Name:

triphenyl phosphite

Constituent 3

Reference substance name:

Diisodecyl phenyl phosphite

EC Number:

247-098-3

EC Name:

Diisodecyl phenyl phosphite

Cas Number:

25550-98-5

Molecular formula:

C26H47O3P

IUPAC Name:

Reaction products of triphenyl phosphite and isodecanol (1:2)

Constituent 4

Reference substance name:

Grouped, low level constituents (1) - see description

Molecular formula:

C21H29O3P and C23H33O3P

IUPAC Name:

Grouped, low level constituents (1) - see description

Constituent 5

Reference substance name:

Grouped, low level constituents (2) - see description

Molecular formula:

N/A

IUPAC Name:

Grouped, low level constituents (2) - see description

Constituent 6

Reference substance name:

Triisodecyl phosphite

EC Number:

246-998-3

EC Name:

Triisodecyl phosphite

Cas Number:

25448-25-3

Molecular formula:

C30H63O3P

IUPAC Name:

Phosphorus acid, triisodecyl ester

Constituent 7

Reference substance name:

Grouped, low level constituents (3) - see description

Molecular formula:

N/A

IUPAC Name:

Grouped, low level constituents (3) - see description

Test material form:

liquid

Test animals

Species:

rabbit

Strain:

New Zealand White

Test system

Type of coverage:

occlusive

Preparation of test site:

other: both abraded and unabraded skin were treated

Vehicle:

unchanged (no vehicle)

Controls:

yes

Amount / concentration applied:

0.5 gram of test material was applied to each test site.

Duration of treatment / exposure:

24-hr exposure

Observation period:

Readings were taken at 24 hours, immediately after removal of wrap, and at 72 hours (48 hours post exposure).

Number of animals:

6 animals

Details on study design:

Scoring for erythema and oedema were done using a standarized 0-4 grading system as described in the guideline.

Results and discussion

In vivo

Results

Irritation parameter:

primary dermal irritation index (PDII)

Basis:

mean

Time point:

other: 72 hours

Score:

1

Irritant / corrosive response data:

Slight erythema was reported in all animals, more on the abraded skin than unabraded skin. No Oedema was reported.

Applicant's summary and conclusion

Interpretation of results:

slightly irritating

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

There was slight irritation in tested rabbits.

Executive summary:

There was slight irritation in tested rabbits. The reported PDII was 1.