Registration Dossier
Registration Dossier
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EC number: 701-341-4 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 40 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
The NOAEL for reproductive and developmental effects from the multigenerational study of TPP, a close analog of DPDP, is 40 mg/kg bw/day (the top dose). The overall NOAEL from this study was 15 mg/kg bw/day due to systemic effects not related to reproductive or developmental endpoints.
Short description of key information:
There is no evidence of reproductive performance or developmental effects from TPP, analog to DPDP.
Justification for selection of Effect on fertility via oral route:
There is a reliable reproductive and developmental effects study of TPP, a close analog to DPDP.
Effects on developmental toxicity
Description of key information
There were no developmental or reproductive effects in a reliable study of TPP, a close chemical analog to DPDP.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 40 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
The NOAEL for reproductive and developmental effects from the multigenerational study of TPP, a close chemical analog of DPDP, is 40 mg/kg bw/day (the top dose). The overall NOAEL from this study was 15 mg/kg bw/day due to systemic effects not related to reproductive or developmental endpoints.
Justification for selection of Effect on developmental toxicity: via oral route:
There is a reliable reproductive and developmental effects study of TPP, a close analog to DPDP.
Justification for classification or non-classification
No specific effects on toxicity related to the reproductive or developmental endpoints, as such DPDP is not classified as a reproductive hazard.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
