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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study performed under GLP. All relevant validity criteria were met.
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
inspected: Novermber 2007; signature: November 2008
Type of method:
gas saturation method
Temp.:
25 °C
Vapour pressure:
0.59 Pa
Remarks on result:
other: Extrapolated from ln P v. 1/T curve
Temp.:
30 °C
Vapour pressure:
0.91 Pa
Temp.:
40 °C
Vapour pressure:
2.6 Pa
Temp.:
50 °C
Vapour pressure:
5.5 Pa

Calculation of the Vapour Pressure

The vapour pressure of the test item has been calculated for each determination using

 

Pvp = WxRxT / VxM

where:

Pvp = vapour pressure [Pa] (calculated)

W = mass of evaporated test item [ug] (determined by analysis)

R = gas constant= 8.314 J/K mol

T = temperature [K] (measured)

V = volume of nitrogen at test temperature [ mL] (determined from flow rate)

M = molar mass oftest item (components reported in the full study report)

Performance of the test

1. Three different flow rates were used at each temperature. Higher flow rates did not lead to lower vapor pressures, which means that the nitrogen

was saturated with test item under the conditions of the test.

2. Trapping efficiency of the test item in the first cooling trap was very good. Over 99% of the test item was trapped in the first cooling trap.

3. The calibration curve had the following parameters within the range of 0.4126 μg/mL and 127.78 μg/mL : y = a x^b where: b = 1.0048, a = 5.6087 and r2 = 0.9992

 

Table 2.0 – vapour pressure determination of the test item

Column

Temperature

[°C]

Volume V2 #1

[mL

Amount in trap 1

[μg]

Amount in trap 2 [μg]

Total amount [μg]

Vapour Pressure [Pa]

Mean vapour pressure [Pa]

1

 

4638

297.177

0.825

298.002

0.95

 

2

 

5910

355.168

0.825

355.994

0.89

 

3

29.85

7025

433.733

0.825

434.559

0.91

0.91

 

 

 

 

 

 

 

 

1

 

79073

12858.037

16.577

12874.614

2.5

 

2

 

100198

17291.240

7.729

17298.970

2.6

 

3

40.00

119324

20884.825

19.158

20903.983

2.7

2.6

 

 

 

 

 

 

 

 

1

 

3533

1250.588

0.825

1251.413

5.6

 

2

 

4507

1560.578

0.825

1561.403

5.4

 

3

49.80

5329

1890.532

0.825

1891.358

5.6

5.5

 

 

 

 

 

 

 

 

#1 : corrected volume at test temperature as calculated under ‘volume correction’

Conclusions:
The vapour pressure of the test item has been determined to be 0.59 Pa at 25 °C.
Executive summary:

The vapour pressure was determined using EU Method A.4 and OECD TG 104 using the gas saturation method under GLP. To ensure saturation control, three different flow rates were used at each temperature. In the determination higher flow rates did not lead to lower vapour pressures, indicating that the nitrogen was saturated with test item under the conditions of the test. The mean vapour pressure was 30°C: 0.91 Pa ; 40°C: 2.6 Pa and 40°C: 5.5 Pa respectively. The vapour pressure of the test item was extrapolated from the vapour pressure curve (ln Pvp versus 1/T) and was calculated to be 0.59 Pa at 25°C.

Description of key information

Vapour Pressure: 0.59 Pa at 25 °C, EU Method A.4 – gas saturation method, 2009

Key value for chemical safety assessment

Vapour pressure:
0.59 Pa
at the temperature of:
25 °C

Additional information

Key Study : EU Method A.4, 2009 : The vapour pressure was determined using EU Method A.4 and OECD TG 104 using the gas saturation method under GLP. To ensure saturation control, three different flow rates were used at each temperature. In the determination higher flow rates did not lead to lower vapour pressures, indicating that the nitrogen was saturated with test item under the conditions of the test. The mean vapour pressure was 30°C: 0.91 Pa ; 40°C: 2.6 Pa and 40°C: 5.5 Pa respectively. The vapour pressure of the test item was extrapolated from the vapour pressure curve (ln Pvp versus 1/T) and was calculated to be 0.51 Pa at 25°C.