Registration Dossier
Registration Dossier
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EC number: 950-112-7 | CAS number: 347377-00-8
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no guideline specified
- Principles of method if other than guideline:
- Diffraction particle size distribution
- GLP compliance:
- no
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- 2,4-Hexadienoic acid, 1,1’-[2-ethyl-2-[[(1-oxo-2,4-hexadien-1-yl)oxy]methyl]-1,3-propanediyl] ester
- EC Number:
- 950-112-7
- Cas Number:
- 347377-00-8
- Molecular formula:
- C24H32O6
- IUPAC Name:
- 2,4-Hexadienoic acid, 1,1’-[2-ethyl-2-[[(1-oxo-2,4-hexadien-1-yl)oxy]methyl]-1,3-propanediyl] ester
Constituent 1
Results and discussion
Particle sizeopen allclose all
- Percentile:
- D10
- Mean:
- >= 61.62 - <= 74.25 µm
- Remarks on result:
- other: six samples tested
- Percentile:
- D50
- Mean:
- >= 414.5 - <= 468.1 µm
- Remarks on result:
- other: six samples tested
- Percentile:
- D90
- Mean:
- >= 653 - <= 868.9 µm
- Remarks on result:
- other: six samples tested
Applicant's summary and conclusion
- Conclusions:
- The study was performed in accordance with generally accepted scientific standards and described in sufficient detail and therefore reliability of Klimisch 2 has been assigned.
The particle size distribution was investigated based on the theory of laser diffraction with the following results:
D10: 61.62 - 74.25 μm
D50 (mass median diameter, MMD): 414.5 - 468.1 µm
D90 = 653.0 - 868.9 μm - Executive summary:
The particle size distribution of the test substance was investigated (non-GLP, 2019) based on the theory of laser diffraction with the following results:
D10: 61.62 - 74.25 μm
D50 (mass median diameter, MMD): 414.5 - 468.1 µm
D90 = 653.0 - 868.9 μm
The inhalation of particles has to be regarded as follows:
- ca. 16% are <100 µm (inhalable fraction)
- 0% are <10 µm (thoracic fraction)
- 0% are < 4µm (respirable fraction)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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