Registration Dossier
Registration Dossier
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EC number: 209-984-8 | CAS number: 600-14-6
Categories
- Category name:
- Penta-2,3-dione acute toxicity category
Justifications and discussions
- Category definition:
- Scenario 6, “Different compounds have the same type of effect(s)”
- Category rationale:
- 1. CATEGORY HYPOTHESIS
This read-across hypothesis is based on a category approach. Within the category, it is hypothesised that, based on structural similarity, the physico-chemical and toxicological properties are likely to be similar or follow a regular pattern in category members. Of the category approaches detailed in the RAAF guidance document, Scenario 6, “Different compounds have the same type of effect(s)” is considered the most appropriate hypothesis for this read-across. Scenario 6 is further defined such that “No relevant variations in properties observed among source substances and the same strength predicted for the target substance”. AEs specific to Scenario 6 in the RAAF document are considered in the read-across document.
2. CATEGORY JUSTIFICATION
The structural similarities between the target and the source substances presented in the document supporting the category approach. Adequate, reliable data indicate that the target and source substances have similar physico-chemical and toxicity profiles that support the application of the category approach as an appropriate read-across method. The target substance is of comparable molecular weight to the majority of the source substances, and the only source substance that is larger than the target substance would be expected to dissociate into isomers of the target substance. These isomers would be of equal molecular weight. Consequently, it is considered that any toxicity observed with any of the source substances presented in this category will be similar to the toxicity of the target.
3. APPLICABILITY DOMAIN OF THE CATEGORY
The structural similarities between the target and the source substances presented in the document supporting the category approach. The target substance is of comparable molecular weight to the majority of the source substances.
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