Azelaic acid, calcium salt (1:1)

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

02 January - 10 April 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

March 04, 2016.

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

July 27, 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Version / remarks:

March 1998

Deviations:

no

GLP compliance:

yes

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 13502 and 13995
- Expiration date of the lot/batch: 19 December 2020
- Purity test date: Not reported

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature

Atm. press.:

1 013.25 hPa

Decomposition:

yes

Decomp. temp.:

225 °C

Preliminary test

Starting at 475°C, the weight of the sample decreased significantly. At 497°C, the sample weight had decreased by 25%. After the experiment, a black charred residue remained in the sample container (original colour: white) and a black residue was observed on the lid of the sample container. The change of the colour indicated reaction and/or decomposition of the test item.

Main test           

A broad endothermic effect was observed between 100°C and 200°C directly followed by a strong exothermic and small endothermic effect starting at 225°C. The first endothermic effect was most likely obtained due the evaporation of impurities. The exothermic and second endothermic effect was probably obtained due to reaction and/or decomposition of the test item.

After the experiment, a light yellow residue remained in the sample container (original colour: white). The change of the colour indicated reaction and/or decomposition of the test item.

In order to investigate the first endothermic effect, Experiment 2 was stopped directly after the endothermic effect. After the experiment, the residue in the sample container was unchanged (original colour: white). It demonstrated that the endothermic effect was probably obtained by the evaporation of impurities.

Conclusions:

No melting temperature could be determined. Reaction and/or decomposition of the test item starting at 225°C (498K) was observed.

Executive summary:

The melting temperature of the test item was determined using differential scanning calorimetry (DSC). Reaction and/or decomposition of the test item was observed during the experiment starting at 225°C (498K). Melting of the test item was not observed below the temperature at which reaction and/or decomposition started. Based on this, the melting temperature of the test item could not be determined.

The study was conducted according to OECD 102 and EC A.1 guidelines and is GLP-compliant and therefore is considered as reliable without restrictions.

Description of key information

The melting temperature of the test item could not be determined. Reaction and/or decomposition of the test item was observed during the experiment starting at 225°C (498K).

Additional information

The study to determine the melting temperature of the test item was conducted according to OECD 102 and EC A.1 guidelines using differential scanning calorimetry (DSC) (Volic 2019).

The study was conducted according to standard guidelines and is GLP-compliant and therefore is considered as reliable without restrictions (Klimisch 1).