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Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2004-01-29 to 2004-03-10
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
0.7
Temp.:
25 °C
Remarks on result:
other: No pH value was given in the report

Table 1 logPow of the test item

 

Retention time in min

mean

k

log k

log Pow

Injection 1

Injection 2

Injection 3

Test item

2.53

2.54

2.54

2.537

0.220

-0.6585

0.683

Conclusions:
Based on the results of this study, the octanol/water partition coefficient of the test item was determined to be logPow = 0.7.
Executive summary:

A study was conducted according to guideline 92/69/EWG A.8 in order to determine the octanol/water partition coefficient of the test item. The HPLC method was applied and three measurements were performed. Based on the results of this study logPow of 0.7 was determined for the test item.

Description of key information

The octanol/water partition coefficient of the test item was determined to be logPow = 0.7 (reference 4.7 -1).

Key value for chemical safety assessment

Log Kow (Log Pow):
0.7
at the temperature of:
25 °C

Additional information

A study was conducted according to guideline 92/69/EWG A.8 in order to determine the octanol/water partition coefficient of the test item. The HPLC method was applied and three measurements were performed. Based on the results of this study logPow of 0.7 was determined for the test item.