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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
Hygienic standard for dichlorantin and its transformation product dimethylhydantoin in an aqueous medium
Author:
Korolev AA, Vasilenko VE, Sidorova MV, Zdorova OV-
Year:
1982
Bibliographic source:
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 47(6), Pg. 76, 1982.

Materials and methods

GLP compliance:
not specified

Test material

Specific details on test material used for the study:
Identity: 5,5-Dimethylhydantoin (CAS RN 77-71-4)
Purity: No information provided

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
8 430 mg/kg bw
Clinical signs:
other: The following linical signs were reported: LUNGS, THORAX, OR RESPIRATION: dyspnea BEHAVIORAL: withdrawal, somnolence (general depressed activity)

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute oral LD50 for 5,5-Dimethylhydantoin was determined to be 8430 mg/kg in guinea pig.