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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
no
Type of method:
column elution method
Key result
Water solubility:
7.45 mg/L
Conc. based on:
test mat. (dissolved fraction)
Incubation duration:
3 h
Temp.:
20 °C
pH:
6.6
Remarks on result:
other: mean value
Water solubility:
7.17 mg/L
Conc. based on:
test mat. (dissolved fraction)
Incubation duration:
3 h
Temp.:
20 °C
pH:
6.6
Remarks on result:
other: flow rate: 25.0 mL/h
Water solubility:
7.89 mg/L
Conc. based on:
test mat. (dissolved fraction)
Incubation duration:
3 h
Temp.:
20 °C
pH:
6.6
Remarks on result:
other: flow rate 13.1 mL/h
Water solubility:
7.29 mg/L
Conc. based on:
test mat. (dissolved fraction)
Incubation duration:
3 h
Temp.:
20 °C
pH:
6.6
Remarks on result:
other: flow rate 6.5 mL/h
Details on results:
All samples showed very good correspondence. Standard deviation within the samples as well as all over the plateau was very low.
At each flow rate, more than 5 samples were taken and measured because after 5 sam-ples still an upward tendency (flow 3) or a downward tendency (flow 1 and 2) was visible.
Because the second flow showed a higher solubility than the first flow, a third flow was performed.
Because no further increasing solubility, the test was finished after flow 3.
All used fractions showed differences < 30%, compared with the fraction, taken before.
Mean solubility of L-Tyrosine, N-acetyl-O-(4-methoxyphenyl)-3,5-dinitro-, ethyl ester was determined with 7.45 ± 0.38 mg/L.
No observations arousing doubts concerning the accuracy of the results and the validity of the study were made.
Conclusions:
At the plateau, the concentration of L-Tyrosine, N-acetyl-O-(4-methoxyphenyl)-3,5-dinitro-, ethyl ester in water had reached:

7.45 ± 0.38 mg/L at 20 ± 0.5 °C
= 7.45 ± 0.38 * 10-3 kg/m3 (SI units)
(Mean of three flows)

Description of key information

In a study according to OECD 105 a test item concentration of  7.45 mg/L ± 0.38 mg/L (mean ± standard deviation) at 20.0 ± 0.5 °C was calculated.

Key value for chemical safety assessment

Water solubility:
7.45 mg/L
at the temperature of:
20 °C

Additional information