Registration Dossier
Registration Dossier
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EC number: 282-029-0 | CAS number: 84082-82-6 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Salix alba, Salicaceae.
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No information on the toxicokinetics of the registration substance is available. However, some information is available on one of the main consitituents, salicin.
According to a report of the European Medicines Agency dated 31.1.2017: "Assessment report on Salix [various species including S. purpurea L., S. daphnoides Vill., S. fragilis L.], cortex" salicin can be hydrolysed by intestinal bacteria in the intestine of rats to its main metabolite saligenin. Salicin and saligenin can then be further transported unchanged through the intestinal wall.
In in vitro studies saligenin was transformed to salicylic acid by homogenised liver, lung and kidney and salicin was partially metabolised to saligenin and salicic acid after incubation with homogenised kidney from rats.
Due to the metabolism and the low lipophilicity of the components of the registration substance a bioaccumulation potential is not expected.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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