Registration Dossier
Registration Dossier
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EC number: 243-500-6 | CAS number: 20073-51-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March to April 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2,6-bis[[bis(2-hydroxyethyl)amino]methyl]-4-nonylphenol
- EC Number:
- 243-500-6
- EC Name:
- 2,6-bis[[bis(2-hydroxyethyl)amino]methyl]-4-nonylphenol
- Cas Number:
- 20073-51-2
- Molecular formula:
- C25H46N2O5
- IUPAC Name:
- 2,6-bis({[bis(2-hydroxyethyl)amino]methyl})-4-nonylphenol
- Test material form:
- liquid: viscous
Constituent 1
Test animals / tissue source
- Species:
- other: bovine
Test system
- Amount / concentration applied:
- 750 μL (undiluted) POLIOL MB 600 in normal saline
- Duration of treatment / exposure:
- 10 min.
- Duration of post- treatment incubation (in vitro):
- 10 min.
Results and discussion
In vitro
Results
- Irritation parameter:
- in vitro irritation score
- Value:
- ca. 74.56
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
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