1,3,5-tris[3-(trimethoxysilyl)propyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1990

Report date:

1990

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

26155-70-8

IUPAC Name:

26155-70-8

Constituent 2

Reference substance name:

1,3,5-tris[3-(trimethoxysilyl)propyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione

EC Number:

247-465-8

EC Name:

1,3,5-tris[3-(trimethoxysilyl)propyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione

Cas Number:

26115-70-8

Molecular formula:

C21H45N3O12Si3

IUPAC Name:

tris[3-(trimethoxysilyl)propyl]-1,3,5-triazinane-2,4,6-trione

Test material form:

liquid: viscous

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 200-300 g
- Fasting period before study: the rats were fasted overnight prior to dosing
- Housing: no data
- Diet: appropriate commercial diet, ad libitum
- Water: municipal water, ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: animal chamber
- Exposure chamber volume: 100 to 151 L
- Method of holding animals in test chamber: no data
- Source and rate of air: The vapour is produced by enclosing approximately 100 g of the test material in a sealed chamber.
- Method of conditioning air: A mixing fan periodically agitates the chamber atmosphere to aid in distribution of the vapour. Oxygen is added for static exposures to maintain oxygen content of 20 % in the chamber.
- Method of particle size determination: no data
- Treatment of exhaust air: no data
- Temperature, humidity, pressure in air chamber: no data

TEST ATMOSPHERE
- Brief description of analytical method used: no data
- Samples taken from breathing zone: no data


TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: no data
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): no data

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

6 h

Concentrations:

substantially saturated vapour

No. of animals per sex per dose:

5 males and 5 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: individual body weights were recorded on days 0, 7 and 14. Frequencies of observations for clinical signs of toxicity were not clarified.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and body weight.

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

other: substantially saturated vapour

Based on:

test mat.

Exp. duration:

6 h

Remarks on result:

other: No deaths occurred

Mortality:

No deaths occurred during the 14-day observation period following 6-hour exposure.

Clinical signs:

other: No clinical signs of toxicity were observed after 6-hour exposure to substantially saturated vapour of the test item.

Body weight:

Expected body weight gain was observed in all test animals.

Gross pathology:

No macroscopic abnormalities were noted at necropsy.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

In the acute inhalation toxicity study for tris[3-(trimethoxysilyl)propyl]-1,3,5-triazinane-2,4,6-trione, conducted according to a protocol similar to OECD test guideline, but without information about GLP compliance, no mortality was observed in rats after 6-hour exposure to substantially saturated vapour of the test item.