Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute oral toxicity: similar to OECD TG 401: LD50 4100 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Quality of whole database:
The acute oral toxicity result is of sufficient quality and adequate for this dossier.

Additional information

Acute oral toxicity:

In an acute oral toxicity study performed similar to OECD 401 (pre-OECD and GLP), 10 rats were administered the test substance orally at dose levels of 2560, 3200, 4000 or 5000 mg/kg bw. The animals were observed for mortality and clinical signs for 14 days. Necropsy was performed after 14 days. Mortality was observed at all dose levels. Clinical signs included lethargy, piloerection, blood on nose, flaccid, ataxia and diarrhea. Necropsy findings included white nodules and dark areas in the lung, mottled and dark liver and kidneys, orange-red areas in the stomach and intestines and dark or enlarged spleen. The acute oral LD50 for the test substance in rats was determined to be 4100 mg/kg bw.

Acute dermal toxicity:

In an acute dermal toxicity study, which was performed similar to OECD 402, 10 rabbits received a dermal application of 5000 mg/kg bw of the test material and were observed for 14 days. The dermal LD50 exceeded 5000 mg/kg bw.

Justification for classification or non-classification

The substance does not have to be classified for acute oral and dermal toxicity in accordance with EU CLP (EC 1272/2008 and its amendments).