Registration Dossier
Registration Dossier
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EC number: 201-132-3 | CAS number: 78-67-1
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Title:
- No information
- Author:
- Rusin, V.Y.: Gig. Truda Profzabol. (1958), 247-251|(published 1959);|cited in: TSCATS: OTS 0000937, Doc. ID. FYI-OTS-0794-0937,|Haskell Laboratory for E.I. Dupont de Nemours & Co., 1-30-84
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- EC Number:
- 201-132-3
- EC Name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- Cas Number:
- 78-67-1
- Molecular formula:
- C8H12N4
- IUPAC Name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- Details on test material:
- 2,2'-azobisisobutyronitrile; no data on purity of the compound
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Duration of treatment / exposure:
- 10 days
- Frequency of treatment:
- 2 h/d
Doses / concentrations
- Remarks:
- no data
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Post-exposure period: none
Results and discussion
Results of examinations
- Description (incidence):
- one rat died
- Description (incidence and severity):
- Morphological changes similar to those observed after intoxication with nitriles and cyanides were found.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Five rats were exposed to vapours produced by heating of the test
substance to 70-80 degrees Centigrade. According to
the authors, HCN concentration did not exceed 1.4-1.6 mg/m3
(1.4-1.6x10E-3 mg/l). One rat died. Morphological changes similar to
those observed after intoxication with nitriles and cyanides were found.
Only secondary literature; no
further data.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
