Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-158-7 | CAS number: 631-41-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- The single dose toxicity of some glycols and derivatives
- Author:
- Smyth, H. F. et al.
- Year:
- 1 941
- Bibliographic source:
- J Ind Hyg Toxicol 23 (6): 259-268
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tetrakis(2-hydroxyethyl)ammonium hydroxide
- EC Number:
- 211-158-7
- EC Name:
- Tetrakis(2-hydroxyethyl)ammonium hydroxide
- Cas Number:
- 631-41-4
- Molecular formula:
- C8H20NO4.HO
- IUPAC Name:
- tetrakis(2-hydroxyethyl)azanium hydroxide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Diet (e.g. ad libitum): adequate diet of Purina chows, and fresh vegetables
- Water (e.g. ad libitum): ad libitum
- Weight at study initiation: 90 - 120 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 250 mg/kg bw
- Mortality:
- no data
- Clinical signs:
- other: no data
Applicant's summary and conclusion
- Conclusions:
- The LD50 was 2250 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
