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EC number: 701-284-5 | CAS number: 2137881-70-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- It is considered appropriate to address the data requirements for reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid by read-across to the available studies on structurally similar substances.
Reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid is comprised of formic acid (free) up to 59%, propylidynetrimethanol (trimethylolpropane, TMP) up to 35%, and pentaerythritol up to 19.6%.
Short-term aquatic invertebrate toxicity studies are available on ammonium formate (which is structurally similar to formic acid), propylidynetrimethanol (trimethylolpropane, TMP), and pentaerythritol. The data requirements for reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid are addressed by read-across to ammonium formate, propylidynetrimethanol (TMP) and pentaerythritol. - Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Specific details on test material used for the study:
- Ammonium formate, propylidynetrimethanol (trimethylolpropane, TMP), and pentaerythritol are being used as a read across for 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid.
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 365 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Remarks on result:
- other: Key data from ammonium formate study
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Remarks on result:
- other: Key data from pentaerythritol study
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 13 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: immobility
- Remarks on result:
- other: Key data from TMP study
- Details on results:
- The key data from short-term aquatic invertebrate toxicity studies on ammonium formate, propylidynetrimethanol (trimethylolpropane, TMP), and pentaerythritol are used for weight of evidence read across to reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The short-term toxicity of the target substance, reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid, to aquatic invertebrates was estimated to be 48 h EC50 = 365 mg/L, based on a worst case read-across study on ammonium formate exposure to D. magna.
- Executive summary:
Short-term studies are available on the acute toxicity to Daphnia for the read-across substances ammonium formate, propylidynetrimethanol (trimethylolpropane, TMP) and pentaerythritol:
A 48 h acute toxicity test was carried out to assess the effects of ammonium formate on Daphnia magna. The 48 h EC50 was found to be 365 mg/L, while the NOEC was determined to be 180 mg/L.
The 48 h acute toxicity of TMP to D. magna was studied under static conditions. Daphnids were exposed to the substance at nominal concentrations of 5,000; 7,500; 10,000; 15,000, 20,000, 25,000; 40,0000 mg/L. Immobilization was observed at 24 and 48 h. The 48 h EC50 was 13,000 mg/L (based on nominal concentrations).
The 24 h EC50 for D. magna exposed to pentaerythritol is >1000 mg/L (the highest nominal exposure concentration tested). No immobility was observed during the study, therefore the corresponding no-observed effect concentration (NOEC) was 1000 mg/L.
Reference
Description of key information
The lowest available EC50 for acute toxicity to Daphnia is 365 mg/L for ammonium formate.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 365 mg/L
Additional information
Short-term studies are available on the acute toxicity to Daphnia for the read-across substances ammonium formate, propylidynetrimethanol (trimethylolpropane, TMP) and pentaerythritol:
A 48 h acute toxicity test was carried out to assess the effects of ammonium formate on Daphnia magna. The 48 h EC50 was found to be 365 mg/L, while the NOEC was determined to be 180 mg/L.
The 48 h acute toxicity of TMP to D. magna was studied under static conditions. Daphnids were exposed to the substance at nominal concentrations of 5,000; 7,500; 10,000; 15,000, 20,000, 25,000; 40,0000 mg/L. Immobilization was observed at 24 and 48 h. The 48 h EC50 was 13,000 mg/L (based on nominal concentrations).
The 24 h EC50 for D. magna exposed to pentaerythritol is >1000 mg/L (the highest nominal exposure concentration tested). No immobility was observed during the study, therefore the corresponding no-observed effect concentration (NOEC) was 1000 mg/L.
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