Formic acid, manufacture of, by-products from

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Justification for type of information:

It is considered appropriate to address the data requirements for reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid by read-across to the available studies on structurally similar substances.
Reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid is comprised of formic acid (free) up to 59%, propylidynetrimethanol (trimethylolpropane, TMP) up to 35%, and pentaerythritol up to 19.6%.
Hydrolysis studies are available on formic acid, propylidynetrimethanol (trimethylolpropane, TMP), and pentaerythritol. The data requirements for reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid are addressed by read-across to formic acid, propylidynetrimethanol (TMP) and pentaerythritol.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Specific details on test material used for the study:

Formic acid, propylidynetrimethanol (trimethylolpropane, TMP), and pentaerythritol are being used as a read across for 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid.

Transformation products:

not specified

pH:

4

Temp.:

50 °C

DT50:

> 5 d

Remarks on result:

other: no hydrolysis could be observed

Remarks:

Data from formic acid study

pH:

7

Temp.:

50 °C

DT50:

> 5 d

Remarks on result:

other: no hydrolysis could be observed

Remarks:

Data from formic acid study

pH:

9

Temp.:

50 °C

DT50:

> 5 d

Remarks on result:

other: no hydrolysis could be observed

Remarks:

Data from formic acid study

pH:

4

Temp.:

25 °C

DT50:

> 1 yr

Remarks on result:

other: Data from TMP study

pH:

7

Temp.:

25 °C

DT50:

> 1 yr

Remarks on result:

other: Data from TMP study

pH:

9

Temp.:

25 °C

DT50:

> 1 yr

Remarks on result:

other: Data from TMP study

Remarks on result:

other: No sign of hydrolysis was seen under the conditions investigated.

Remarks:

Data from Pentaerythritol study

Details on results:

The key data from hydrolysis studies on formic acid, propylidynetrimethanol (trimethylolpropane, TMP), and pentaerythritol are used for weight of evidence read across to reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid.

Validity criteria fulfilled:

yes

Conclusions:

Based on supporting read across studies on formic acid, propylidynetrimethanol (trimethylolpropane, TMP), and pentaerythritol, it is concluded that reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid is hydrolytically stable.

Executive summary:

Hydrolysis studies are available for the read-across substances formic acid, propylidynetrimethanol (trimethylolpropane, TMP) and pentaerythritol:

 

A 5 day test was carried out to according to EC method C7 to determine the rate of hydrolysis of formic acid. At pH values of 4, 7 and 9 and at a temperature of 50°C each, no hydrolysis occured within the test duration of approximately 5 days.

 

The hydrolytic behaviour of TMP was tested according to OECD 111. The hydrolytic half-life at pH 4.0, 7.0, and 9.0 was determined to be greater than 1 year. Therefore, TMP is hydrolytically stable.

 

A hydrolysis study was conducted according to OECD 111 to determine the hydrolysis in water at different pH values of pentaerythritol. Solutions of the test substance in aqueous buffers at pHs, 7, and 9 were stored in a heating cabinet at 50°C for five days, and samples at 50°C were then analysed with samples which had been stored at -20°C and the difference calculated. It was concluded that no hydrolysis was observed under the conditions investigated.

Description of key information

The hydrolysis studies for the read-across substance indcate that the substance will be hydrolytically stable.

Additional information

Hydrolysis studies are available for the read-across substances formic acid, propylidynetrimethanol (trimethylolpropane, TMP) and pentaerythritol:

A 5 day test was carried out to according to EC method C7 to determine the rate of hydrolysis of formic acid. At pH values of 4, 7 and 9 and at a temperature of 50°C each, no hydrolysis occured within the test duration of approx. 5 days.

The hydrolytic behaviour of TMP was tested according to OECD 111. The hydrolytic half-life at pH 4.0, 7.0, and 9.0 was determined to be greater than 1 year. Therefore, TMP is hydrolytically stable.

A hydrolysis study was conducted by Perstorp AB, to determine the hydrolysis in water at different pH values of the test substance Pentaerythritol. The study was conducted according to the OECD test guideline. Solutions of the test substance in aqueous buffers at pHs, 7, and 9 were stored in a heating cabinet at 50°C for five days. At the end of the storage period, the samples at 50°C were analysed with samples which had been stored at -20°C, and the difference calculated. It was concluded that no hydrolysis was observed under the conditions investigated.