Registration Dossier
Registration Dossier
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EC number: 940-806-8 | CAS number: -
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Both, the reaction mass of (1R,2R)-, (1R,2S)- (1S, 2R) and (1S,2S)-Isomers of 2,3-dihydro-2,6-dimethyl-1H-inden-1-amine (EC no. 940-806-8) and the selected source substance (1R,2S)-2,3-dihydro-2,6-dimethyl-1H-inden-1-amine (CAS 752984-24-0) are heterocyclic primary amines that have chemically similar structures.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
- Target Substance: the reaction mass of (1R,2R)-, (1S,2S)- (1S, 2R) and (1R,2S)-Isomers of 2,3-dihydro-2,6-dimethyl-1H-inden-1-amine (EC no. 940-806-8)
- Source Substance: (1R,2S)-2,3-Dihydro-2,6-dimethyl-1H-inden-1-amine (CAS 752984-24-0)
Target and source substance are manufactured as substances of high purity and it is, therefore, not likely that they contain impurities which might have an influence on the read-across approach applied.
3. ANALOGUE APPROACH JUSTIFICATION
The source substance is considered suitable for the analogue approach, as their chemical structure is similar to that of the target chemical. Both, source and target substance are isomers of the same chemical composition.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- (1R,2S)-2,6-dimethyl-2,3-dihydro-1H-inden-1-amine
- EC Number:
- 700-140-9
- Cas Number:
- 752984-24-0
- Molecular formula:
- C11H15N
- IUPAC Name:
- (1R,2S)-2,6-dimethyl-2,3-dihydro-1H-inden-1-amine
- Test material form:
- liquid
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 3.1 g/L
- Temp.:
- 20 °C
- pH:
- 10.05 - 10.6
- Remarks on result:
- other: Test Medium: Distilled water, RSD: 8.5 %
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): soluble (1000-10000 mg/L)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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