Registration Dossier
Registration Dossier
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EC number: 930-930-0 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish early-life stage toxicity
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
Long term studies to fish are not deemed necessary for both calcium hydroxide and calcium peroxide. On the one hand, calcium hydroxyde dissociates in calcium and hydroxyl ions, so there will be no intake of calcium hydroxide as such, nor will calcium hydroxide prevail under its original form in the organisms. On the other hand, caldium peroxide hydrolyses to calcium hydroxide and hydrogen peroxide. Hydrogen peroxide has a short half-life in natural waters due to the activity of micro-organisms, and therefore long-term exposure of aquatic biota, i.a. invertebrates to hydrogen peroxide originating from anthropogenic sources is considered rather improbable. Furthermore, hydrogen peroxide is continuously formed in the environment and is ubiquitous in fresh- and seawater at natural background concentrations from some micrograms to some tens of microgram per litre. Accordingly, fish can be considered evolutionary adapted to hydrogen peroxide in this range of concentrations. In consideration of these points, a prolonged toxicity test in fish is not necessary.
Reference
Description of key information
Data waiving (study scientifically not necessary): Long term studies to fish are not deemed necessary for both calcium hydroxide and calcium peroxide. On the one hand, calcium hydroxyde dissociates in calcium and hydroxyl ions, so there will be no intake of calcium hydroxide as such, nor will calcium hydroxide prevail under its original form in the organisms. On the other hand, caldium peroxide hydrolyses to calcium hydroxide and hydrogen peroxide. Hydrogen peroxide has a short half-life in natural waters due to the activity of micro-organisms, and therefore long-term exposure of aquatic biota, i.a. invertebrates to hydrogen peroxide originating from anthropogenic sources is considered rather improbable. Furthermore, hydrogen peroxide is continuously formed in the environment and is ubiquitous in fresh- and seawater at natural background concentrations from some micrograms to some tens of microgram per litre. Accordingly, fish can be considered evolutionary adapted to hydrogen peroxide in this range of concentrations. In consideration of these points, a prolonged toxicity test in fish is not necessary.
Key value for chemical safety assessment
Additional information
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