Sodium 6-diazo-5,6-dihydro-5-oxonaphthalene-1-sulphonate

Endpoint summary

Description of key information

OECD 401: LD50 (oral, rat) > 2000 mg/kg bw

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1981-08-03 to 1981-08-19

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Remarks:

Only a brief summary of the study is available

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not applicable

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Specific details on test material used for the study:

not further specified

Species:

rat

Strain:

Wistar

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
-Source: Hoechst AG, Frankfurt, Germany
-Females (if applicable) nulliparous and non-pregnant: yes
-Weight at study initiation: 180 - 198 g
-Fasting period before study: 16 hours before until up to 2 hours after treatment
-Housing: groupwise
-Diet: ad libitum
-Water: ad libitum

IN-LIFE DATES: From: day 1 To: day 15

Route of administration:

oral: gavage

Vehicle:

other: sesame oil

Details on oral exposure:

VEHICLE
-Concentration in vehicle: 250 g/L
-Dosing volume: no data

Doses:

5000 mg/kg

No. of animals per sex per dose:

10 f

Control animals:

no

Details on study design:

-Duration of observation period following administration: 14 days
-Frequency of observations: daily
-Frequency of weighing: weekly
-Necropsy of survivors performed: yes

Statistics:

no data

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Remarks on result:

not determinable due to absence of adverse toxic effects

Mortality:

All rats survived the observation period

Clinical signs:

No signs of toxicity were seen in dosed rats

Body weight:

The body weight development of the rats was inconspicuous during the study

Gross pathology:

The gross pathological examination revealed no organ alterations

Study design

In this study performed equivalent to OECD GL 401 the test item was tested for acute toxicity in female rats after single oral administration of 5000 mg/kg body weight.

Results

No signs of toxicity and no deaths during the course of the study were seen in dosed rats. The body weight development of the rats was inconspicuous during the study and the gross pathological examination revealed no organ alterations.

Conclusion

Based on the result of this study, it is concluded that the test material has no acute toxic potential and that the LD50 value is higher than 5000 mg/kg after single oral administration in female rats.

Interpretation of results:

GHS criteria not met

Conclusions:

Based on the result of this study, it is concluded that the test material has no acute toxic potential and that the LD50 value is higher than 5000 mg/kg after single oral administration in female rats.

Executive summary:

Based on the result of this study, it is concluded that the test material has no acute toxic potential and that the LD50 value is higher than 5000 mg/kg after single oral administration in female rats.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

2 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Justification for classification or non-classification

Based on the provided information there is no need for classification according to the EU Regulation (EC) No 1272/2008 on Classification,Lab elling and Packaging of Substances and Mixtures, as amended for the 10th time in Regulation (EU) No 2017/776.