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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

The lowest result is a 7 day NOEC of 0.96 mg/L for ethylbenzene. The estimated NOELR values from TLM QSAR are 1.672 - 2.122 mg/L.

The experimental value was used for chemical safety assessment.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
0.96 mg/L

Additional information

Two chronic aquatic invertebrate ecotoxicity studies are available, with ethylbenzene, m- and p-xylene as the test substances. Niederlehner et al (1998) investigated the effects of m-xylene and ethylbenzene on Ceriodaphnia dubia reproduction over 7 days. The NOEC of 0.96 mg/L from Niederlehner et al (1998) for chronic toxicity of ethylbenzene to invertebrates was taken by Environment Canada as the critical toxicity value for ethylbenzene toxicity to aquatic species in the Draft Screening Assessment Report (Environment Canada 2014). Bjornestad et al (2005) investigated the effects of p-xylene on Daphnia magna reproduction over 21 days following OECD 211. Both studies included analytical confirmation of the exposure concentrations.

The three reported NOECs from studies are similar, 0.96 mg/L (ethylbenzene) 1.17 mg/L (m-xylene) and 1.57 mg/L (p-xylene). The lowest value will be taken forward.

A TLM-EqP modeling framework was used to support values derived experimentally and are presented as supporting studies.

The estimated NOELR values from TLM QSAR were 1.672 - 2.122 mg/L.